One of the few books to cover all aspects of cyclin-dependent kinases (CDKs), Inhibitors of
Cyclin-dependent Kinases as Anti-tumor Agents provides an overview of CDKs as molecular …

The discussion on cell proliferation cannot be continued without taking a look at the cell
cycle regulatory machinery. Cyclin-dependent kinases (CDKs), cyclins, and CDK inhibitors …

Cyclin-dependent kinases (CDKs) are core components of the cell cycle machinery that
govern the transition between phases during cell cycle progression. Genes involved in cell …

The cyclin dependent kinases, Cdks, are potential targets for new anticancer therapy.
Dysregulation of the cell cycle is common during tumorigenesis, and inhibition of certain …

Cell-cycle dysregulation is one of the cardinal characteristics of neoplastic cells. For this
reason, small molecule inhibitors targeting cyclin-dependent kinases (CDKs), of which …

Cancer drug discovery is one of the most rapidly changing areas of pharmaceutical
research. Uncontrolled proliferation is a hallmark of cancer cells. Over the past two decades …

Cell cycle progression through each phase is regulated by heterodimers formed by cyclin-
dependent kinases (CDKs) and their regulatory partner proteins, the cyclins. Together they …

Over the past two decades there has been a great deal of interest in the development of
inhibitors of the cyclin-dependent kinases (CDKs). This attention initially stemmed from …

Importance of the field: Abnormalities in protein phosphorylation by cyclin-dependent
kinases (CDKs) have been observed in numerous major human diseases, which has …

Members of the family of cyclin-dependent kinases (CDKs) fulfill important and partly
overlapping roles in the regulation of the cell proliferation cycle and the RNA polymerase-II …