DNA methylation is one of the epigenetic modifications of the genome, the essence of which
is the attachment of a methyl group to nitrogenous bases. In the eukaryote genome, cytosine …

Epigenetic modifications are responsible for the modulation of gene expression without
affecting the nucleotide sequence. The observed changes in transcriptional activity of genes …

DNA methylation is one of the most intensely studied epigenetic modifications in mammals.
In normal cells, it assures the proper regulation of gene expression and stable gene …

DNA methylation is one of epigenetic mechanisms regulating gene expression. The
methylation pattern is determined during embryogenesis and passed over to differentiating …

Methylation of CpG dinucleotides is an epigenetic mechanism involved in the regulation of
gene expression in mammals. The patterns of CpG methylation are specie and tissue …

DNA methylation is involved in genomic imprinting, tissue and stage specific gene
regulation, X chromosome inactivation and especially necessary in normal mammalian …

DNA methylation is an integral part of the mechanism of a remodeling and modification of
the chromatin structure. The global complex net of chromatin modification and remodeling …

Regulation of gene expression is a complex process. It includes a great number of steps
from control of mRNA synthesis to posttranslational modification of proteins. Epigenetic …

Methylation of cytosines at their carbon-5 position plays an important role both during
development and in tumorgenesis. The methylation occurs almost exclusively in CpG …

The study of the biological role of DNA methylation in vertebrates has involved considerable
controversy. Research in this area has proceeded well despite the complexity of the subject …