Abstract This chapter entitled “Cell Cycle, DNA Damage Repair Systems, and Impact of
Redox Regulation in Cancer” introduces the cell cycle components in normal cells and …

Redox reactions are known to regulate many important cellular processes. In this review, we
focus on the role of redox regulation in DNA repair both in direct regulation of specific DNA …

DNA repair pathways have long been recognized as important in protecting the genome
from damage caused by endogenous and exogenous DNA damaging agents. However, the …

Significance: Reactive oxygen species (ROS) are generated by exogenous and
environmental genotoxins, but also arise from mitochondria as byproducts of respiration in …

Highlights•APE1 protein repairs small base lesions in the DNA base excision repair
pathway.•APE1 converts oxidized inactive transcription factors to a reduced and active …

The apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a
multifunctional enzyme involved in DNA repair and activation of transcription factors through …

Abstract© 2017 Elsevier Ltd. All rights reserved. The DNA damage response (DDR),
comprising DNA repair and cell-cycle checkpoint pathways, is an attractive target for cancer …

With our growing understanding of the pathways involved in cell proliferation and signaling,
targeted therapies, in the treatment of cancer are entering the clinical arena. New and …

Apurinic/apyrimidinic endonuclease–reduction/oxidation factor 1 (APE1/ref. 1, also called
APE1) is a multifunctional enzyme with essential tasks in DNA repair and …

This chapter entitled “ROS, Redox Regulation, and Anticancer Therapy” includes all redox-
regulated cancer therapy events. Here in this chapter initially conventional therapy …