[HTML][HTML] m6A methyltransferase METTL3 contributes to sympathetic hyperactivity post-MI via promoting TRAF6-dependent mitochondrial ROS production
P Yang, Y Wang, W Ge, Y Jing, H Hu, J Yin… - Free Radical Biology …, 2023 - Elsevier
Abstract Objectives N6-methyladenosine (m6A) is the most prevalent post-translational
modification in eukaryotic mRNA. Recently, m6A editing modified by methyltransferase-like …
modification in eukaryotic mRNA. Recently, m6A editing modified by methyltransferase-like …
[HTML][HTML] m6A methyltransferase METTL3 participated in sympathetic neural remodeling post-MI via the TRAF6/NF-κB pathway and ROS production
L Qi, Y Wang, H Hu, P Li, H Hu, Y Li, K Wang… - Journal of Molecular and …, 2022 - Elsevier
Objective Sudden cardiac death caused by ventricular arrhythmias (VAs) is the main cause
of high mortality in patients with myocardial infarction (MI). Sympathetic neural remodeling …
of high mortality in patients with myocardial infarction (MI). Sympathetic neural remodeling …
New insights into the central sympathetic hyperactivity post‐myocardial infarction: Roles of METTL3‐mediated m6A methylation
L Qi, H Hu, Y Wang, H Hu, K Wang, P Li… - Journal of Cellular …, 2022 - Wiley Online Library
Ventricular arrhythmias (VAs) triggers by sympathetic nerve hyperactivity contribute to
sudden cardiac death in myocardial infarction (MI) patients. Microglia‐mediated …
sudden cardiac death in myocardial infarction (MI) patients. Microglia‐mediated …
Loss of m6A methyltransferase METTL3 promotes heart regeneration and repair after myocardial injury
R Gong, X Wang, H Li, S Liu, Z Jiang, Y Zhao… - Pharmacological …, 2021 - Elsevier
Abstract Aims N6-Methyladenosine (m 6 A), one of the important epigenitic modifications, is
very commom in messenger RNAs (mRNAs) of eukaryotes, and has been involved in …
very commom in messenger RNAs (mRNAs) of eukaryotes, and has been involved in …
METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes
H Song, X Feng, H Zhang, Y Luo, J Huang, M Lin… - Autophagy, 2019 - Taylor & Francis
ABSTRACT N6-methyladenosine (m6A) mRNA modifications play critical roles in various
biological processes. However, no study addresses the role of m6A in macroautophagy …
biological processes. However, no study addresses the role of m6A in macroautophagy …
[HTML][HTML] METTL3 boosts mitochondrial fission and induces cardiac fibrosis after ischemia/reperfusion injury
L Ma, X Chang, J Gao, Y Zhang, Y Chen… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
METTL3, an RNA methyltransferase enzyme, exerts therapeutic effects on various
cardiovascular diseases. Myocardial ischemia-reperfusion injury (MIRI) and subsequently …
cardiovascular diseases. Myocardial ischemia-reperfusion injury (MIRI) and subsequently …
[HTML][HTML] Mettl14 attenuates cardiac ischemia/reperfusion injury by regulating wnt1/β-catenin signaling pathway
P Pang, Z Qu, S Yu, X Pang, X Li, Y Gao… - Frontiers in Cell and …, 2021 - frontiersin.org
N6-methyladenosine (m6A) methylation in RNA is a dynamic and reversible modification
regulated by methyltransferases and demethylases, which has been reported to participate …
regulated by methyltransferases and demethylases, which has been reported to participate …
[HTML][HTML] METTL3 improves cardiomyocyte proliferation upon myocardial infarction via upregulating miR-17-3p in a DGCR8-dependent manner
K Zhao, C Yang, J Zhang, W Sun, B Zhou, X Kong… - Cell Death …, 2021 - nature.com
Myocardial infarction (MI), one of the most severe types of heart attack, exerts a strong
negative effect on heart muscle by causing a massive and rapid loss of cardiomyocytes …
negative effect on heart muscle by causing a massive and rapid loss of cardiomyocytes …
The N6-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy
Background: N 6-Methyladenosine (m6A) methylation is the most prevalent internal
posttranscriptional modification on mammalian mRNA. The role of m6A mRNA methylation …
posttranscriptional modification on mammalian mRNA. The role of m6A mRNA methylation …
[HTML][HTML] The m6A methyltransferase METTL3 modifies PGC-1α mRNA promoting mitochondrial dysfunction and oxLDL-induced inflammation in monocytes
X Zhang, X Li, H Jia, G An, J Ni - Journal of Biological Chemistry, 2021 - ASBMB
Mitochondrial biogenesis and energy metabolism are essential for regulating the
inflammatory state of monocytes. This state is partially controlled by peroxisome proliferator …
inflammatory state of monocytes. This state is partially controlled by peroxisome proliferator …