Hereditary defects in the repair of DNA damage are implicated in a variety of diseases, many
of which are typified by neurological dysfunction and/or increased genetic instability and …

DNA single-strand breaks (SSBs) are among the most common lesions arising in human
cells, with tens to hundreds of thousands arising in each cell, each day. Cells have efficient …

DNA single-strand breaks (SSBs) are amongst the commonest DNA lesions arising in cells,
with many tens of thousands induced in each cell each day. SSBs arise not only from …

Each day tens of thousands of DNA single-strand breaks (SSBs) arise in every cell from the
attack of deoxyribose and DNA bases by reactive oxygen species and other electrophilic …

The efficient repair of DNA double-strand breaks is crucial in safeguarding the genomic
integrity of organisms. Responses to double-strand breaks include complex signal …

A number of DNA repair disorders are known to cause neurological problems. These
disorders can be broadly characterised into early developmental, mid-to-late developmental …

DNA damage is a form of cell stress and injury that has been implicated in the pathogenesis
of many neurologic disorders, including amyotrophic lateral sclerosis, Alzheimer disease …

Defective responses to DNA single-or double-strand breaks can result in neurological
disease, underscoring the critical importance of DNA repair for neural homeostasis. Human …

DNA double-strand breaks (DSBs) can be generated by a variety of genotoxic agents,
including ionizing radiation and radiomimetic chemicals. They can also occur when DNA …

The ability to respond to genotoxic stress is a prerequisite for the successful development of
the nervous system. Mutations in various DNA repair factors can lead to human diseases …