Up to 25% of the E. coli strains isolated from the feces of healthy humans harbor the pks
genomic island encoding the synthesis of colibactin, a genotoxic metabolite. Evidence is …

Colibactin is a secondary metabolite encoded by the pks gene island identified in several
Enterobacteriaceae, including some pathogenic Escherichia coli (E. coli) commonly …

Colibactin, a bacterial genotoxin produced by E. coli strains harboring the pks genomic
island, induces cytopathic effects, such as DNA breaks, cell cycle arrest, and apoptosis …

Colibactin-producing bacteria are abundant in the gut microbiota of colorectal cancer
tumours and promote colon tumorigenesis in mouse models. Now, a new study …

Colibactin is a genotoxic molecule, produced primarily by Escherichia coli. Colibactin
causes DNA damage that may lead to colorectal cancer. Here we review recent advances in …

The biosynthetic machinery for the production of colibactin is encoded by 19 genes (clbA–S)
within the pks pathogenicity island harboured by many E. coli of the B2-phylogroup …

The complex reservoir of metabolite-producing bacteria in the gastrointestinal tract
contributes tremendously to human health and disease. Bacterial composition, and by …

Cyclomodulins are bacterial toxins that interfere with the eukaryotic cell cycle. A new
cyclomodulin called colibactin, which is synthetized by the pks genomic island, was …

Background Colibactin is a genotoxin that induces DNA double-strand breaks that may lead
to carcinogenesis and is produced by Escherichia coli strains harboring the pks island …

INTRODUCTION Members of the human gut microbiota have been implicated in the
development and progression of colorectal cancer (CRC). These CRC-associated …