Brain-derived neurotrophic factor (BDNF)—a member of a small family of secreted proteins
that includes nerve growth factor, neurotrophin 3 and neurotrophin 4—has emerged as a …

During development, neural networks are established in a highly organized manner, which
persists throughout life. Neurotrophins play crucial roles in the developing nervous system …

The proteins of the mammalian neurotrophin family (nerve growth factor (NGF), brain-
derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5)) …

Since its discovery, brain-derived neurotrophic factor (BDNF) has spawned a literature that
now spans 35 years of research. While all neurotrophins share considerable overlap in …

Since its discovery almost three decades ago, the secreted neurotrophin brain-derived
neurotrophic factor (BDNF) has been firmly implicated in the differentiation and survival of …

Brain-derived neurotrophic factor (BDNF) is the most ubiquitous and intensively studied
member of the family of neurotrophins in the CNS. The transcriptional regulation of BDNF is …

Neurotrophic factors are traditionally viewed as secretory proteins that regulate long-term
survival and differentiation of neurons. The role of neurotrophic factors in the structural …

Examples of signaling molecules that are devoted to neuronal development at the exclusion
of other functions are scarce. It may then come as no surprise to learn that a family of …

Among all neurotrophins, brain-derived neurotrophic factor (BDNF) stands out for its high
level of expression in the brain and its potent effects on synapses. It is now widely accepted …

The neurotrophins are a family of closely related proteins that were first identified as survival
factors for sympathetic and sensory neurons and have since been shown to control a …