Animal models are essential tools for addressing fundamental scientific questions about
skeletal diseases and for the development of new therapeutic approaches. Traditionally …

Danio rerio (zebrafish) is an elective model organism for the study of vertebrate
development because of its high degree of homology with human genes and organs …

Zebrafish are teleosts (bony fish) that share with mammals a common ancestor belonging to
the phylum Osteichthyes, from which their endoskeletal systems have been inherited …

Developmental osteogenesis and pathologies of mineralized tissues are areas of intense
investigations in the mammalian field, but different from other areas of organ formation and …

For many years bone research has been mainly performed in mice, chicken, cell culture
systems or human material from the clinic. In this review, we describe the features of …

The zebrafish is as an important vertebrate animal model system for studying developmental
processes, gene functions and signalling pathways. It is also used as a model system for the …

Advances in next‐generation sequencing have transformed our ability to identify genetic
variants associated with clinical disorders of the musculoskeletal system. However, the …

In 2019, the Nosology Committee of the International Skeletal Dysplasia Society provided an
updated version of the Nosology and Classification of Genetic Skeletal Disorders. This is a …

Exercise promotes gain in bone mass through adaptive responses of the vertebrate
skeleton. This mechanism counteracts age-and disease-related skeletal degradation, but …

Small teleost fish such as zebrafish and medaka are increasingly studied as models for
human skeletal diseases. Efficient new genome editing tools combined with advances in the …