Understanding ayahuasca effects in major depressive disorder treatment through invitro metabolomics and bioinformatics

FS Zandonadi, AAR Silva, AAS Melo… - Analytical and …, 2023 - Springer
Emerging insights from metabolomic-based studies of major depression disorder (MDD) are
mainly related to biochemical processes such as energy or oxidative stress, in addition to …

[HTML][HTML] Metabolomics and integrated network analysis reveal roles of endocannabinoids and large neutral amino acid balance in the ayahuasca experience

F Madrid-Gambin, A Gomez-Gomez… - Biomedicine & …, 2022 - Elsevier
There has been a renewed interest in the potential use of psychedelics for the treatment of
psychiatric conditions. Nevertheless, little is known about the mechanism of action and …

[HTML][HTML] Neuroprotective potential of Ayahuasca and untargeted metabolomics analyses: applicability to Parkinson's disease

A Katchborian-Neto, WT Santos, KJ Nicácio… - Journal of …, 2020 - Elsevier
Ethnopharmacology relevance Ayahuasca is a tea produced through decoction of
Amazonian plants. It has been used for centuries by indigenous people of South America …

Status of metabolomic measurement for insights in Alzheimer's disease progression—What is missing?

C Yin, AC Harms, T Hankemeier, A Kindt… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is an aging-related neurodegenerative disease, leading to the
progressive loss of memory and other cognitive functions. As there is still no cure for AD, the …

The potential for metabolomics in the study and treatment of major depressive disorder and related conditions

J Duan, P Xie - Expert Review of Proteomics, 2020 - Taylor & Francis
Introduction Major depressive disorder (MDD) is a common mental disease, associated with
a debilitating condition and high prevalence. Although the underlying mechanism of MDD …

High-throughput metabolomic approach revealed the acupuncture exerting intervention effects by perturbed signatures and pathways

Y Zhang, A Zhang, G Yan, W Cheng, H Sun… - Molecular …, 2014 - pubs.rsc.org
Metabolomics can capture global changes and the overall physiological status in
biochemical networks and pathways in order to elucidate sites of perturbations. High …

[HTML][HTML] Emerging application of metabolomics on Chinese herbal medicine for depressive disorder

X Gu, X Gao, J Cheng, C Xia, Y Xu, L Yang… - Biomedicine & …, 2021 - Elsevier
Depressive disorder is a kind of emotional disorder that is mainly manifested with
spontaneous and persistent low mood. Its etiology is complex and still not fully understood …

Combined metabolomics and proteomics analysis of major depression in an animal model: perturbed energy metabolism in the chronic mild stressed rat cerebellum

W Shao, J Chen, S Fan, Y Lei, H Xu, J Zhou… - Omics: a journal of …, 2015 - liebertpub.com
Major depressive disorder (MDD) is a highly prevalent, debilitating mental illness of
importance for global health. However, its molecular pathophysiology remains poorly …

Comparative metabolomics analysis reveals key metabolic mechanisms and protein biomarkers in Alzheimer's disease

Z Dai, T Hu, S Su, J Liu, Y Ma, Y Zhuo… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease (AD) is one of the most common progressive neurodegenerative
diseases, accompanied by global alterations in metabolic profiles. In the past 10 years, over …

Metabolomics on depression: A comparison of clinical and animal research

Y Wang, X Cai, Y Ma, Y Yang, CW Pan, X Zhu… - Journal of Affective …, 2024 - Elsevier
Background Depression is a major cause of suicide and mortality worldwide. This study
aims to conduct a systematic review to identify metabolic biomarkers and pathways for major …