The development of latency reversing agents that potently reactivate HIV without inducing
global T cell activation would benefit the field of HIV reservoir research and could pave the …

Latency reversal agents (LRAs) have proven to induce HIV-1 transcription in vivo but are
ineffective at decreasing the size of the latent reservoir in antiretroviral treated patients. The …

Reactivation of latent viral reservoirs is on the forefront of HIV-1 eradication research.
However, it is unknown if latency reversing agents (LRAs) increase the level of viral …

BACKGROUND A central challenge to emerging efforts to cure HIV infection is the
persistence of quiescent but replication-competent proviral genomes in resting CD4+ T …

The presence of T cell reservoirs in which human immunodeficiency virus (HIV) establishes
latency by integrating into the host genome represents a major obstacle to an HIV cure and …

Combinatory antiretroviral therapy (cART) reduces human immunodeficiency virus type 1
(HIV-1) replication but is not curative because cART interruption almost invariably leads to a …

The 'shock and kill'approach to cure human immunodeficiency virus (HIV) includes
transcriptional induction of latent HIV-1 proviruses using latency-reversing agents (LRAs) …

One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …

Abstract Purpose of Review For most people living with HIV (PLWH), treatment with effective
antiretroviral therapy (ART) results in suppression of viremia below the limit of detection of …

A proposed strategy to cure HIV uses latency-reversing agents (LRAs) to reactivate latent
proviruses for purging HIV reservoirs. A variety of LRAs have been identified, but none has …