Form follows function: nanoparticle shape and its implications for nanomedicine

C Kinnear, TL Moore, L Rodriguez-Lorenzo… - Chemical …, 2017 - ACS Publications
This review is a comprehensive description of the past decade of research into
understanding how the geometry and size of nanoparticles affect their interaction with …

Non-spherical micro-and nanoparticles for drug delivery: Progress over 15 years

N Kapate, JR Clegg, S Mitragotri - Advanced Drug Delivery Reviews, 2021 - Elsevier
Shape of particulate drug carries has been identified as a key parameter in determining their
biological outcome. In this review, we analyze the field of particle shape as it shifts from …

Non-spherical micro-and nanoparticles: fabrication, characterization and drug delivery applications

R Mathaes, G Winter, A Besheer… - Expert opinion on drug …, 2015 - Taylor & Francis
Introduction: Micro-and nanoparticles in drug and vaccine delivery have opened up new
possibilities in pharmaceutics. In the past, researchers focused mainly on particle size …

Role of nanoparticle mechanical properties in cancer drug delivery

Y Hui, X Yi, F Hou, D Wibowo, F Zhang, D Zhao… - ACS …, 2019 - ACS Publications
The physicochemical properties of nanoparticles play critical roles in regulating nano-bio
interactions. Whereas the effects of the size, shape, and surface charge of nanoparticles on …

[HTML][HTML] Unambiguous observation of shape effects on cellular fate of nanoparticles

Z Chu, S Zhang, B Zhang, C Zhang, CY Fang, I Rehor… - Scientific reports, 2014 - nature.com
Cellular fate of nanoparticles is vital to application of nanoparticles to cell imaging, bio-
sensing, drug delivery, suppression of drug resistance, gene delivery and cytotoxicity …

[HTML][HTML] Physics in nanomedicine: Phenomena governing the in vivo performance of nanoparticles

LA Lane - Applied Physics Reviews, 2020 - pubs.aip.org
Nanomedicine aims to increase the effectiveness of therapeutic and diagnostic agents by
exploiting unique properties that arise when operating at the nanoscale. Despite the recent …

The effect of particle shape on cellular interaction and drug delivery applications of micro-and nanoparticles

AB Jindal - International journal of pharmaceutics, 2017 - Elsevier
Encapsulation of therapeutic agents in nanoparticles offers several benefits including
improved bioavailability, site specific delivery, reduced toxicity and in vivo stability of …

Novel approaches for drug delivery systems in nanomedicine: effects of particle design and shape

N Daum, C Tscheka, A Neumeyer… - Wiley Interdisciplinary …, 2012 - Wiley Online Library
The identification of novel drug candidates for the treatment of diseases like cancer,
infectious diseases, or allergies (especially asthma) assigns new tasks for pharmaceutical …

Nanotechnology based drug delivery systems: Does shape really matter?

S Shah, P Famta, D Bagasariya, K Charankumar… - International Journal of …, 2022 - Elsevier
As of today, the era of nanomedicine has brought numerous breakthroughs and overcome
challenges in the treatment of various disorders. Various factors like size, charge and …

Nanoparticle geometry and surface orientation influence mode of cellular uptake

H Herd, N Daum, AT Jones, H Huwer, H Ghandehari… - ACS …, 2013 - ACS Publications
In order to engineer safer nanomaterials, there is a need to understand, systematically
evaluate, and develop constructs with appropriate cellular uptake and intracellular fates. The …