Pancreatic stellate cells (PSCs) are activated following loss of cytoplasmic vitamin A (retinol)-
containing lipid droplets, which is a key event in the process of fibrogenesis of chronic …

Pancreatic stellate cells (PSCs) are essentially involved in the development of pancreatic
fibrosis, a constant feature of chronic pancreatitis and pancreatic cancer. Profibrogenic …

Pancreatic fibrosis, a prominent feature of chronic pancreatitis (CP), induces persistent and
permanent damage in the pancreas. Pancreatic stellate cells (PSCs) provide a major source …

BACKGROUND & AIMS: Patients with pancreatic ductal adenocarcinoma are deficient in
vitamin A, resulting in activation of pancreatic stellate cells (PSCs). We investigated whether …

Background and aims: Activated pancreatic stellate cells (PSCs) are implicated in the
production of alcohol induced pancreatic fibrosis. PSC activation is invariably associated …

Objectives Retinoic acid (RA) has important functions during embryonic development being
involved in cell growth and differentiation. Although approved for the treatment of acute …

Trans-resveratrol, also known as 3, 5, 4′-trihydroxy-trans-stilbene, is a natural stilbenoid
found at high concentration in skins of red grapes and berries. Over the recent years, it has …

Until now, no specific therapies are available to inhibit pancreatic fibrosis, a constant
pathological feature of chronic pancreatitis and pancreatic cancer. One major reason is the …

Pre-clinical models have shown that targeting pancreatic stellate cells with all-trans-retinoic-
acid (ATRA) reprograms pancreatic stroma to suppress pancreatic ductal adenocarcinoma …

Background Our study and several studies have reported that in some cancers, including
pancreatic ductal adenocarcinoma (PDAC), the expression of squamous lineage markers …