Immunoglobulin light chain systemic amyloidosis

A Dispenzieri, G Merlini - Plasma Cell Dyscrasias, 2016 - Springer
Immunoglobulin light chain amyloidosis (AL) is a rare, complex disease caused by
misfolded free light chains produced by a usually small, indolent plasma cell clone. Effective …

Immunoglobulin light chain amyloidosis

G Merlini, RL Comenzo, DC Seldin… - Expert review of …, 2014 - Taylor & Francis
Primary light chain amyloidosis is the most common form of systemic amyloidosis and is
caused by misfolded light chains that cause proteotoxicity and rapid decline of vital organ …

The challenge of systemic immunoglobulin light-chain amyloidosis (Al)

G Palladini, RL Comenzo - … and Fibrillogenesis in Cerebral and Systemic …, 2012 - Springer
The cardiac involvement and associated mortality that occur in systemic AL amyloidosis
remain among the most challenging aspects of the systemic amyloid-related diseases …

Systemic Light Chain Amyloidosis

V Sanchorawala - New England Journal of Medicine, 2024 - Mass Medical Soc
Key Points Systemic Light Chain Amyloidosis Immunoglobulin light chain (AL) amyloidosis
is a rare disease that occurs when a plasma cell disorder produces monoclonal light chains …

Systemic light chain amyloidosis: an update for treating physicians

G Merlini, AD Wechalekar… - Blood, The Journal of the …, 2013 - ashpublications.org
In immunoglobulin light chain amyloidosis a small, indolent plasma cell clone synthesizes
light chains that cause devastating organ damage. Early diagnosis, based on prompt …

Nonchemotherapy treatment of immunoglobulin light chain amyloidosis

L Van Doren, S Lentzsch - Acta Haematologica, 2020 - karger.com
Immunoglobulin light chain amyloidosis (AL amyloidosis) is a rare, life-threatening disease
characterized by the deposition of misfolded proteins in vital organs such as the heart, the …

Diagnosis and management of systemic light chain AL amyloidosis

D Bhutani, S Lentzsch - Pharmacology & Therapeutics, 2020 - Elsevier
AL amyloidosis is a plasma cell disorder leading to the production and extracellular
deposition of abnormal immunoglobulin light chains called amyloid. The pathogenesis of the …

Fibril-directed therapies in systemic light chain AL amyloidosis

D Bhutani, S Leng, S Lentzsch - Clinical Lymphoma Myeloma and …, 2019 - Elsevier
Immunoglobulin light chain amyloidosis (AL amyloidosis) is a plasma cell disorder leading
to the production and extracellular deposition of abnormal immunoglobulin light chains …

[HTML][HTML] Recent advances in understanding and treating immunoglobulin light chain amyloidosis

T Badar, A D'Souza, P Hari - F1000Research, 2018 - ncbi.nlm.nih.gov
Immunoglobulin (Ig) light chain (AL) amyloidosis is a clonal plasma cell disorder
characterized by misfolded Ig light chain deposition in vital organs of the body, resulting in …

Treatment options for relapsed/refractory systemic light-chain (AL) amyloidosis: current perspectives

S Sarosiek, V Sanchorawala - Journal of Blood Medicine, 2019 - Taylor & Francis
Systemic immunoglobulin light chain (AL) amyloidosis is a disorder characterized by the
production of clonal serum free light chains that misfold, aggregate, and deposit in vital …