Exposure to ozone causes decrements in pulmonary function, a response associated with
alterations in lung lipids. Pulmonary lipid homeostasis is dependent on the activity of …

Peroxisome proliferator-activated receptor-gamma (PPARγ) is a nuclear transcription factor
involved in lipid metabolism that is constitutively expressed in the alveolar macrophages of …

Introduction Pulmonary innate immunity is impaired in cigarette smokers, because the
abundant oxidants present in cigarette smoke (CS) cause injury to lung cells. Pulmonary …

Chronic obstructive pulmonary disease (COPD) is a highly prevalent, chronic inflammatory
lung disease with limited existing therapeutic options. While modulation of peroxisome …

Peroxisome proliferator-activated receptor (PPAR)-γ is expressed in alveolar macrophages.
The anti-inflammatory potential of the PPAR-γ ligands rosiglitazone and pioglitazone were …

Exposure to ozone (O3) induces lung injury, pulmonary inflammation, and alters lipid
metabolism. During tissue inflammation, specialized pro-resolving lipid mediators (SPMs) …

Peroxisome proliferator-activated receptor-α (PPARα) is implicated in the control of airway
inflammation. However, little is known so far about PPARα expression and regulation in the …

The development of emphysema in humans and mice exposed to cigarette smoke is
promoted by activation of an adaptive immune response. Lung myeloid dendritic cells …

There is considerable interest in the role of peroxisome proliferator activated receptors
(PPARs) as ligand-activated transcription factors in the airways. This study examines the …

Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory condition and
a leading cause of death, with no available cure. We assessed the actions in pulmonary …