LDLRAD2 promotes pancreatic cancer progression through Akt/mTOR signaling pathway

J Li, W Huang, Q Han, J Xiong, Z Song - Medical Oncology, 2021 - Springer
Low-density lipoprotein receptor class A domain containing 2 (LDLRAD2) acts as a protein-
coding gene in a large number of human diseases. However, the potential roles and …

[HTML][HTML] LDLRAD2 overexpression predicts poor prognosis and promotes metastasis by activating Wnt/β-catenin/EMT signaling cascade in gastric cancer

Y Wei, F Zhang, T Zhang, Y Zhang, H Chen… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
The therapeutic strategies for advanced gastric cancer (GC) remain unsatisfying and limited.
Therefore, it is still imperative to fully elucidate the mechanisms underlying GC aggressive …

Low density lipoprotein receptor class A domain containing 4 (LDLRAD4) promotes tumorigenesis of hepatic cancer cells

Z Liu, X Huo, S Zhao, J Yang, W Shi, L Jing, W Li… - Experimental cell …, 2017 - Elsevier
LDLRAD4 was previously identified and shown to be connected with psychiatric disorders.
The structure of LDLRAD4 protein is similar to that of TMEPAI protein, which is …

Lgr4 promotes prostate tumorigenesis through the Jmjd2a/AR signaling pathway

J Zhang, Q Li, S Zhang, Q Xu, T Wang - Experimental Cell Research, 2016 - Elsevier
Lgr4 (leucine-rich repeat domain containing G protein-coupled receptor 4) is implicated in
the transcriptional regulation of multiple histone demethylases in the progression of diverse …

LRG-1 promotes pancreatic cancer growth and metastasis via modulation of the EGFR/p38 signaling

ZB Xie, YF Zhang, C Jin, YS Mao, DL Fu - Journal of Experimental & …, 2019 - Springer
Background The abnormal expression of leucine-rich-alpha-2-glycoprotein 1 (LRG-1) is
reported to be associated with multiple malignancies, but its role in the progression of …

LRP1 as a promising therapeutic target for gastrointestinal tumors: Inhibiting proliferation, invasion and migration of cancer cells

M Zhu, H Shen, B Wang, Y He, J Chen… - Oncology …, 2023 - spandidos-publications.com
Gastrointestinal (GI) cancers are the most common types of tumors worldwide. The lack of
cancer biomarkers and targeted drug resistance are barriers to achieving effective cancer …

[引用][C] LRRC1 promotes proliferation of hepatocellular carcinoma cells via DLG1/YAP signaling pathway

X Xiaoli, Z Haoxiong, Y Bilan, W Bin… - JOURNAL OF NEW …, 2021 - xinyixue.cn
Objective To investigate the mechanism of leucine-rich repeat-containing protein 1 (LRRC1)
in regulating the proliferation of hepatocellular carcinoma (HCC) cells through the discs …

A LETM2-regulated PI3K-Akt signaling axis reveals a prognostic and therapeutic target in pancreatic cancer

S Zhou, Z Zhong, Y Lu, Y Li, H Yao, Y Zhao, T Guo… - Cancers, 2022 - mdpi.com
Simple Summary LEMT2 was a newly discovered protein-encoding gene with little cancer
research and an unclear mechanism. This study aimed to illustrate LETM2 as the crucial …

Over-expression of low-density lipoprotein receptor-related Protein-1 is associated with poor prognosis and invasion in pancreatic ductal adenocarcinoma

A Gheysarzadeh, A Ansari, MH Emami, AE Razavi… - Pancreatology, 2019 - Elsevier
Background Low-density lipoprotein receptor-Related Protein-1 (LRP-1) has been reported
to involve in tumor development. However, its role in pancreatic cancer has not been …

Downregulation of Low-density lipoprotein receptor-related protein 1B (LRP1B) inhibits the progression of hepatocellular carcinoma cells by activating the …

Z Zhen, Z Shen, P Sun - Bioengineered, 2022 - Taylor & Francis
Hepatocellular carcinoma (HCC) has a high recurrence rate and mortality rate even after
surgery. Low-density lipoprotein receptor-related protein 1B (LRP1B) has proven to be …