The primate lentiviral accessory protein Nef downregulates CD4 and major
histocompatibility complex class I (MHC-I) from the cell surface via independent endosomal …

ABSTRACT SERINC3 (serine incorporator 3) and SERINC5 are recently identified host cell
inhibitors of HIV-1 particle infectivity that are counteracted by the viral pathogenesis factor …

SERINC5 is a multipass intrinsic membrane protein that suppresses HIV-1 infectivity when
incorporated into budding virions. The HIV-1 Nef virulence factor prevents viral incorporation …

HIV Nef counteracts cellular host restriction factors SERINC3 and SERINC5, but our
understanding of how naturally occurring global Nef sequence diversity impacts these …

Among the five serine incorporator (SERINC) family members, SERINC5 (Ser5) was
reported to strongly inhibit HIV-1 replication, which is counteracted by Nef. Ser5 produces 5 …

SERINC5 is a host restriction factor that impairs infectivity of HIV-1 and other primate
lentiviruses and is counteracted by the viral accessory protein Nef. However, the importance …

HIV-1 Nef, a protein important for the development of AIDS, has well-characterized effects on
host membrane trafficking and receptor downregulation. By an unidentified mechanism, Nef …

Summary HIV-1-negative factor (Nef) protein antagonizes serine incorporator 5 (SERINC5)
by redirecting this potent restriction factor to the endosomes and lysosomes for degradation …

The Nef protein is an important HIV virulence factor that promotes the degradation of host
proteins to augment virus production and facilitate immune evasion. The best-characterized …

Background The HIV-1 accessory protein, Nef, is decisive for progression to AIDS. In vitro
characterization of the protein has described many Nef activities of unknown in vivo …