[PDF][PDF] Interleukin-33 in tissue homeostasis, injury, and inflammation

AB Molofsky, AK Savage, RM Locksley - Immunity, 2015 - cell.com
Interleukin-33 (IL-33) is a nuclear-associated cytokine of the IL-1 family originally described
as a potent inducer of allergic type 2 immunity. IL-33 signals via the receptor ST2, which is …

Emerging functions of IL-33 in homeostasis and immunity

GK Dwyer, LM D'Cruz… - Annual review of …, 2022 - annualreviews.org
Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated
molecular pattern IL-33 continues to evolve with our understanding of homeostasis and …

New dog and new tricks: evolving roles for IL-33 in type 2 immunity

JM Lott, TL Sumpter, HR Turnquist - Journal of Leucocyte …, 2015 - academic.oup.com
IL-33 is a more recently identified member of the IL-1 cytokine family, expressed in the
nucleus of epithelial cells and released into the extracellular space following tissue damage …

Dual immune regulatory roles of interleukin-33 in pathological conditions

H Guo, EA Bossila, X Ma, C Zhao, Y Zhao - Cells, 2022 - mdpi.com
Interleukin-33 (IL-33), a member of the IL-1 cytokine family and a multifunctional cytokine,
plays critical roles in maintaining host homeostasis and in pathological conditions, such as …

Disease-associated functions of IL-33: the new kid in the IL-1 family

FY Liew, NI Pitman, IB McInnes - Nature Reviews Immunology, 2010 - nature.com
Abstract Interleukin-33 (IL-33), a newly described member of the IL-1 family, is expressed by
many cell types following pro-inflammatory stimulation and is thought to be released on cell …

The IL-33/ST2 axis: Role in health and disease

M De la Fuente, TT MacDonald, MA Hermoso - Cytokine & growth factor …, 2015 - Elsevier
Abstract IL-33, an IL-1 family member, is expressed by many cell types and can regulate
gene transcription. IL-33 is released upon cell necrosis and the precursor form is …

[HTML][HTML] Pleiotropic effects of IL-33 on CD4+ T cell differentiation and effector functions

F Alvarez, JH Fritz, CA Piccirillo - Frontiers in immunology, 2019 - frontiersin.org
IL-33, a member of the IL-1 family of cytokines, was originally described in 2005 as a
promoter of type 2 immune responses. However, recent evidence reveals a more complex …

Interleukin-33 in health and disease

FY Liew, JP Girard, HR Turnquist - Nature Reviews Immunology, 2016 - nature.com
Abstract Interleukin-33 (IL-33)—a member of the IL-1 family—was originally described as an
inducer of type 2 immune responses, activating T helper 2 (TH2) cells and mast cells. Now …

Crucial and diverse role of the interleukin-33/ST2 axis in infectious diseases

O Rostan, MI Arshad, C Piquet-Pellorce… - Infection and …, 2015 - Am Soc Microbiol
ABSTRACT Interleukin-33 (IL-33) has now emerged as a cytokine with diverse and
pleiotropic functions in various infectious and inflammatory diseases. IL-33 is expressed by …

Therapeutic strategies for targeting IL-33/ST2 signalling for the treatment of inflammatory diseases

WY Chen, TH Tsai, JL Yang, LC Li - Cellular Physiology and …, 2018 - karger.com
Abstract Interleukin (IL)-33, a member of the IL-1 family of cytokines, is involved in innate
and adaptive immune responses via interaction with its receptor, ST2. Activation of ST2 …