HIF-1 regulation: not so easy come, easy go
MY Koh, TR Spivak-Kroizman, G Powis - Trends in biochemical sciences, 2008 - cell.com
The hypoxia-inducible factor-1 (HIF-1) is the master regulator of the cellular response to
hypoxia and its expression levels are tightly controlled through synthesis and degradation. It …
hypoxia and its expression levels are tightly controlled through synthesis and degradation. It …
[HTML][HTML] HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1α degradation
E Berra, DE Richard, E Gothié, J Pouysségur - FEBS letters, 2001 - Elsevier
Hypoxia-inducible factor-1α (HIF-1α) plays a central role in oxygen homeostasis. In
normoxia, HIF-1α is a short lived protein, whereas hypoxia rapidly increases HIF-1α protein …
normoxia, HIF-1α is a short lived protein, whereas hypoxia rapidly increases HIF-1α protein …
Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1α
DA Chan, PD Sutphin, SE Yen… - Molecular and cellular …, 2005 - Taylor & Francis
Oxygen-dependent proteolysis is the primary means of regulating the hypoxia-inducible
factor (HIF) family of transcription factors. The alpha-subunit of HIF factor 1 (HIF-1) contains …
factor (HIF) family of transcription factors. The alpha-subunit of HIF factor 1 (HIF-1) contains …
Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1α is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association …
N Sang, J Fang, V Srinivas… - Molecular and cellular …, 2002 - Am Soc Microbiol
Hypoxia-inducible factor 1 complex (HIF-1) plays a pivotal role in oxygen homeostasis and
adaptation to hypoxia. Its function is controlled by both the protein stability and the …
adaptation to hypoxia. Its function is controlled by both the protein stability and the …
[HTML][HTML] PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1α from pVHL-independent degradation
J Zhou, T Schmid, R Frank, B Brüne - Journal of Biological Chemistry, 2004 - ASBMB
Hypoxia inducible factor 1 (HIF-1), a heterodimeric transcription factor composed of HIF-1α
and HIF-1β subunits, serves as a key regulator of metabolic adaptation to hypoxia. The …
and HIF-1β subunits, serves as a key regulator of metabolic adaptation to hypoxia. The …
[HTML][HTML] Constitutive/hypoxic degradation of HIF-α proteins by the proteasome is independent of von Hippel Lindau protein ubiquitylation and the transactivation …
X Kong, B Alvarez-Castelao, Z Lin, JG Castano… - Journal of Biological …, 2007 - ASBMB
The transcriptional activator complex HIF-1 plays a key role in the long term adaptation of
cells and tissues to their hypoxic microenvironment by stimulating the expression of genes …
cells and tissues to their hypoxic microenvironment by stimulating the expression of genes …
Functional regulation of HIF‐1α under normoxia—is there more than post‐translational regulation?
A Kuschel, P Simon, S Tug - Journal of cellular physiology, 2012 - Wiley Online Library
Abstract The hypoxia‐inducible factor‐1 (HIF‐1) is an oxygen‐regulated transcriptional
activator playing a pivotal role in mammalian physiology and disease pathogenesis, eg, HIF …
activator playing a pivotal role in mammalian physiology and disease pathogenesis, eg, HIF …
[HTML][HTML] Stabilization of hypoxia-inducible factor-1α protein in hypoxia occurs independently of mitochondrial reactive oxygen species production
The transcription factor hypoxia-inducible factor-1α (HIF-1α) is a master regulator of the
cellular response to low oxygen. HIF-1α protein accumulates in hypoxia due to inhibition of …
cellular response to low oxygen. HIF-1α protein accumulates in hypoxia due to inhibition of …
Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1α, leading to its oxygen-independent degradation
MY Koh, BG Darnay, G Powis - Molecular and cellular biology, 2008 - Taylor & Francis
The hypoxia-inducible factor 1α (HIF-1α) is the master regulator of the cellular response to
hypoxia. A key regulator of HIF-1α is von Hippel-Lindau protein (pVHL), which mediates the …
hypoxia. A key regulator of HIF-1α is von Hippel-Lindau protein (pVHL), which mediates the …
[HTML][HTML] Hypoxia‐inducible factor‐1α (HIF‐1α) escapes O2‐driven proteasomal degradation irrespective of its subcellular localization: nucleus or cytoplasm
E Berra, D Roux, DE Richard, J Pouysségur - EMBO reports, 2001 - embopress.org
Eukaryotic cells sense oxygen and adapt to hypoxia by regulating a number of genes.
Hypoxia‐inducible factor 1 (HIF‐1) is the 'master'in this pleiotypic response. HIF‐1 …
Hypoxia‐inducible factor 1 (HIF‐1) is the 'master'in this pleiotypic response. HIF‐1 …