[HTML][HTML] Dietary Polyphenols Effects on Focal Adhesion Plaques and Metalloproteinases in Cancer Invasiveness

R Carrano, M Grande, E Leti Maggio, C Zucca, R Bei… - Biomedicines, 2024 - mdpi.com
Focal adhesion plaques (FAPs) play an important role in the communication between cells
and the extracellular matrix (ECM) and in cells' migration. FAPs are macromolecular …

[HTML][HTML] Polyphenolic nutrients in cancer chemoprevention and metastasis: Role of the epithelial-to-mesenchymal (EMT) pathway

H Amawi, CR Ashby Jr, T Samuel, R Peraman… - Nutrients, 2017 - mdpi.com
The epithelial-to-mesenchymal transition (EMT) has received significant interest as a novel
target in cancer prevention, metastasis, and resistance. The conversion of cells from an …

Multifaceted ability of naturally occurring polyphenols against metastatic cancer

Q Zhou, LL Bennett, S Zhou - Clinical and Experimental …, 2016 - Wiley Online Library
Although cancer metastases are known to be the main cause of cancer‐related deaths, truly
effective antimetastatic therapeutics remain scarce in clinical practice. Naturally occurring …

[HTML][HTML] Unveiling the power of flavonoids: A dynamic exploration of their impact on cancer through matrix metalloproteinases regulation

P Rajendran - BioMedicine, 2024 - ncbi.nlm.nih.gov
Cancer stands as a significant contributor to global mortality rates, primarily driven by its
progression and widespread dissemination. Despite notable strides in cancer therapy, the …

Chemopreventive effects of polyphenol-rich extracts against cancer invasiveness and metastasis by inhibition of type IV collagenases expression and activity

K Chojnacka, U Lewandowska - Journal of Functional Foods, 2018 - Elsevier
Natural polyphenols, frequently called secondary metabolites, play an important role in
cancer prevention and treatment. Polyphenols are characterized by high structural diversity …

Augmented cell signaling by natural polyphenols and flavonoids: insights into cancer cell remodeling and prevention

S Dhanasekaran, R Jaganathan - Studies in Natural Products Chemistry, 2018 - Elsevier
Genetic alterations trigger various cell signaling pathways by transforming the cell cycle of a
normal cell into a cancer cell. Flavonoids are abundantly expressed in natural foods which …

Anti-tumor Effects of Polyphenols via Targeting Cancer Driving Signaling Pathways: A Review

K Moar, S Yadav, A Pant, PK Maurya - Indian Journal of Clinical …, 2024 - Springer
The use of drugs in chemotherapy poses numerous side effects. Hence the use of natural
substances that can help in the prevention and cure of the disease is a dire necessity …

Dietary polyphenols in chemoprevention and synergistic effect in cancer: Clinical evidences and molecular mechanisms of action

S Patra, B Pradhan, R Nayak, C Behera, S Das… - Phytomedicine, 2021 - Elsevier
Background Epidemiological studies has revealed that a diet rich in fruits and vegetables
could lower the risk of certain cancers. In this setting, natural polyphenols are potent …

Phytochemicals modulate cancer aggressiveness: A review depicting the anticancer efficacy of dietary polyphenols and their combinations

T Mitra, R Bhattacharya - Journal of Cellular Physiology, 2020 - Wiley Online Library
Cancer is referred to as the “Emperor of all maladies” accounting for the second‐highest
mortality rates worldwide. Major factors associated with cancer lethality are uncontrolled …

Natural Polyphenols in Cancer Management: Promising Role, Mechanisms, and Chemistry

PK Upadhyay, S Singh… - Current Pharmaceutical …, 2024 - ingentaconnect.com
Background: Although cancers emerge rapidly and cancer cells divide aggressively, which
affects our vital organ systems. Recently, cancer treatments are targeted immune systems …