Significant progress has been made towards the development of phosphate prodrugs for
intracellular delivery of monophosphates. Such efforts led to the successful application of the …

Nucleoside monophosphates and monophosphonates have been known for a long time to
exert favorable pharmacological effects upon intracellular delivery. However, their …

Synthetic nucleosides, designed to mimic naturally occurring nucleosides, are important
antiviral and anticancer chemotherapeutic agents. However, nucleosides are not active as …

For many decades, the design of new nucleoside analogs as potential therapeutic agents
focused on both sugar and nucleobase modifications. These nucleoside analogs rely on …

The antiviral efficacy of many nucleoside analogues is strongly dependent on their
intracellular activation by host cellular kinases to yield ultimately the bioactive nucleoside …

In this review, our recent advances in the development of nucleoside di-and nucleoside
triphosphate prodrugs is summarized. Previously, we had developed a successful …

The cytosolic conversion of therapeutically relevant nucleosides into bioactive triphosphates
is often hampered by the inefficiency of the first kinase‐mediated step. Nucleoside …

This chapter surveys several representative examples of current prodrug approaches which
explicitly depend on enzyme‐mediated activation. The chapter discusses several …

The phosphoroamidate (ProTide) approach is a prodrug technology aimed to circumvent
metabolic bottlenecks in the activation of nucleoside-based drugs and optimise their …

Interest in stabilizing, enhancing cellular penetration and altering other pharmacokinetic
properties of polynucleotides and oligonucleotides has been substantial for a number of …