PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability
A Silva, JA Yunes, BA Cardoso… - The Journal of …, 2008 - Am Soc Clin Investig
Mutations in the phosphatase and tensin homolog (PTEN) gene leading to PTEN protein
deletion and subsequent activation of the PI3K/Akt signaling pathway are common in …
deletion and subsequent activation of the PI3K/Akt signaling pathway are common in …
[HTML][HTML] Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN …
AM Gomes, MVD Soares, P Ribeiro, J Caldas… - …, 2014 - ncbi.nlm.nih.gov
Adult B-cell acute lymphoblastic leukemia remains a major therapeutic challenge, requiring
a better characterization of the molecular determinants underlying disease progression and …
a better characterization of the molecular determinants underlying disease progression and …
[HTML][HTML] The PTEN tumor suppressor gene and its role in lymphoma pathogenesis
X Wang, H Huang, KH Young - Aging (Albany NY), 2015 - ncbi.nlm.nih.gov
The phosphatase and tensin homolog gene PTEN is one of the most frequently mutated
tumor suppressor genes in human cancer. Loss of PTEN function occurs in a variety of …
tumor suppressor genes in human cancer. Loss of PTEN function occurs in a variety of …
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia
A Gutierrez, T Sanda, R Grebliunaite… - Blood, The Journal …, 2009 - ashpublications.org
To more comprehensively assess the pathogenic contribution of the PTEN-PI3K-AKT
pathway to T-cell acute lymphoblastic leukemia (T-ALL), we examined diagnostic DNA …
pathway to T-cell acute lymphoblastic leukemia (T-ALL), we examined diagnostic DNA …
PTEN is a tumor suppressor in CML stem cells and BCR-ABL–induced leukemias in mice
C Peng, Y Chen, Z Yang, H Zhang… - Blood, The Journal …, 2010 - ashpublications.org
The tumor suppressor gene phosphatase and tensin homolog (PTEN) is inactivated in many
human cancers. However, it is unknown whether PTEN functions as a tumor suppressor in …
human cancers. However, it is unknown whether PTEN functions as a tumor suppressor in …
The impact of PTEN regulation by CK2 on PI3K-dependent signaling and leukemia cell survival
JT Barata - Advances in enzyme regulation, 2011 - Elsevier
Constitutive activation of phosphoinositide 3-kinase (PI3K)(EC 2.7. 1.153) signaling pathway
is highly prevalent in leukemia and supports tumor cell proliferation and viability. The tumor …
is highly prevalent in leukemia and supports tumor cell proliferation and viability. The tumor …
PTEN Is Inversely Correlated With the Cell Survival Factor Akt/PKB and Is Inactivated Via Multiple Mechanisms in Haematological Malignancies
PLM Dahia, RCT Aguiar, J Alberta… - Human molecular …, 1999 - academic.oup.com
PTEN is a novel tumour suppressor gene that encodes a dual-specificity phosphatase with
homology to adhesion molecules tensin and auxillin. It recently has been suggested that …
homology to adhesion molecules tensin and auxillin. It recently has been suggested that …
PTEN tumor-suppressor: the dam of stemness in cancer
F Luongo, F Colonna, F Calapà, S Vitale, ME Fiori… - Cancers, 2019 - mdpi.com
PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …
Phosphatase and tensin homologue phosphorylation in the C‐terminal regulatory domain is frequently observed in acute myeloid leukaemia and associated with poor …
JW Cheong, JI Eom, HY Maeng, ST Lee… - British journal of …, 2003 - Wiley Online Library
Phosphorylation of PTEN (phosphatase and tensin homologue) affects PTEN protein
stability and function. In this study, phosphorylated PTEN (pPTEN) was observed in 45 (73 …
stability and function. In this study, phosphorylated PTEN (pPTEN) was observed in 45 (73 …