Estrogen appears to be a negative regulator of normal hematopoiesis, Chromosome 6q,
which contains the estrogen receptor (ER) gene, is frequently altered in human …

Southern analysis has shown that DNA from 25% of primary estrogen receptor (ER) α-
negative breast tumors displays aberrant methylation at one site within the ER gene CpG …

Hormonal factors have a profound influence on the development, treatment, and outcome of
breast cancer. The absence of steroid hormone receptors is highly correlated with resistance …

Approximately one third of breast cancers grow independently of estrogen, lack detectable
estrogen receptor (ER) protein, and rarely respond to hormonal treatment. Previous studies …

Hormone therapy is the most effective treatment for patients with estrogen receptor α-
positive breast cancers. However, although resistance occurs during treatment in some …

Promoter methylation has recently been shown to be an alternative to mutation in
inactivating tumor suppressor genes in human neoplasia. Although specific carcinogen …

Progesterone receptor (PR) is an estrogen-stimulated gene which has a CpG island that is
heavily methylated in a significant fraction of estrogen receptor (ER)-negative/PR-negative …

DNA methylation is known to be involved in eukaryotic gene control; it may thus exert effects
during development and tumorigenesis. We have examined the methylation status of the …

We hypothesize that estrogen receptors (ERs) are differentially expressed in endometrial
cancer. To test this hypothesis, we investigated the expression profile of ERα (ERα-A, ERα …

The expressions of two isoforms of human progesterone receptor (PR) are under the control
of the two different promoters. Recent studies revealed differences between these isoforms …