This review aims at describing the beneficial properties of melatonin related to its antioxidant
effects. Oxidative stress, ie, an imbalance between the production of reactive oxygen …

This brief resume enumerates the multiple actions of melatonin as an antioxidant. This
indoleamine is produced in the vertebrate pineal gland, the retina and possibly some other …

Over three centuries ago, the French philosopher René Descartes described the pineal
gland as “the seat of the soul.” However, it was not until the late 1950s that the chemical …

Melatonin was found to be a potent free radical scavenger in 1993. Since then over 800
publications have directly or indirectly confirmed this observation. Melatonin scavenges a …

Melatonin is a potent endogenous free radical scavenger, actions that are independent of its
many receptor-mediated effects. In the last several years, hundreds of publications have …

Oxidative stress has been proven to be related to the onset of a large number of health
disorders. This chemical stress is triggered by an excess of free radicals, which are …

In recent years, relationship between free radicals and oxidative stress with aging, cancer,
atherosclerosis, neurodegenerative disorders, diabetes, and inflammatory diseases became …

Melatonin is an endogenous hormone derived from tryptophan that is mainly released from
the pineal gland in the dark. Melatonin regulates many biological functions such as sleep …

Neurodegeneration is the hallmark of many chronic progressive neurogical disorders
characterized by specific clinical, morphological and biochemical features. Central nervous …

The discovery of melatonin and its derivatives as antioxidants has stimulated a very large
number of studies which have, virtually uniformly, documented the ability of these molecules …