Introduction: Current treatment for metastatic bone pain is mainly palliative. Recent insights
into the molecular mechanisms involved in bone metastases have led to the identification of …

Bone metastases contribute to a significant degree of morbidity in patients with common
cancers through the development of skeletal related events (SRE) such as bone pain and …

Bone metastases are associated with a broad spectrum of clinical sequelae. Pain, reduced
mobility, skeletal complications and treatment-related events reduce quality of life …

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The prevalence of pain and skeletal complications of metastatic bone disease is high and an
important factor, which contributes to decreased quality of life and low survival rate. Bone …

Conventional treatment for metastatic bone pain requires a multidisciplinary approach
(medical therapy, surgery, and radiation), but is primarily palliative. Biphosphonates …

Metastatic bone disease in patients with advanced cancer is frequently associated with
skeletal complications. These can be debilitating, causing pain, impaired functioning and …

Painful metastatic bone disease remains a challenge for physicians. The treatment choices
available are wide and varied, with each having its appropriate place in the management of …

All bone surfaces are periodically remodeled by the coupled and balanced action of
osteoclasts and osteoblasts, of which the activities are regulated by a variety of cytokines …

Up to 90% of patients with metastatic or advanced stage cancer will experience significant
cancer-related pain. Approximately half or more of patients diagnosed with cancer may …