Most patients with cholangiocarcinoma (CCA) develop extrahepatic malignant biliary
obstructions, which require palliative drainage to normalize bilirubin levels and to improve …

The contributions of mesenchymal stem cells (MSCs) to tumour growth and stroma formation
are poorly understood. Tumour cells can transfer genetic information and modulate cell …

Cellular microparticles are vesicular plasma membrane fragments with a diameter of 100–
1,000 nanometres that are shed by cells in response to various physiological and artificial …

Liver cancer remains a global health challenge with a projected incidence of over one
million cases by 2025. Hepatocellular carcinoma (HCC) is a common primary liver cancer …

Cholangiocarcinoma (CCA), the cancer arising from the epithelial cells of bile ducts, is a
prototype of inflammatory-driven cancer. Cytokines released by cancer associated …

Cholangiocarcinoma (CCA) is an aggressive and multifactorial malignancy of the biliary
tract. The carcinogenesis of CCA is associated with genomic and epigenetic abnormalities …

Background & Aims Neutrophils can either promote or inhibit tumor progression, depending
on the tumor microenvironment, via release of cytokines. Neither the factors produced by …

Extracellular microparticles (MPs) can function as drug-delivery vehicles for anticancer
drugs. Here, we show that the softness of MPs derived from tumour-repopulating cells …

Nanocarrier-mediated drug targeting is an emerging strategy for cancer therapy and is being
used, for example, with chemotherapeutic agents for ovarian cancer. Nanocarriers are …

Background Tumor-associated neutrophils (TANs) and macrophages (TAMs) can each
influence cancer growth and metastasis, but their combined effects in intrahepatic …