The V-ATPases in cancer and cell death

F Chen, R Kang, J Liu, D Tang - Cancer gene therapy, 2022 - nature.com
Transmembrane ATPases are membrane-bound enzyme complexes and ion transporters
that can be divided into F-, V-, and A-ATPases according to their structure. The V-ATPases …

The function of V-ATPases in cancer

L Stransky, K Cotter, M Forgac - Physiological reviews, 2016 - journals.physiology.org
The vacuolar ATPases (V-ATPases) are a family of proton pumps that couple ATP hydrolysis
to proton transport into intracellular compartments and across the plasma membrane. They …

Recent insights into the structure, regulation, and function of the V-ATPases

K Cotter, L Stransky, C McGuire, M Forgac - Trends in biochemical …, 2015 - cell.com
The vacuolar (H+)-ATPases (V-ATPases) are ATP-dependent proton pumps that acidify
intracellular compartments and are also present at the plasma membrane. They function in …

Regulation and isoform function of the V-ATPases

M Toei, R Saum, M Forgac - Biochemistry, 2010 - ACS Publications
The vacuolar (H+)-ATPases are ATP-dependent proton pumps that acidify intracellular
compartments and, in some cases, transport protons across the plasma membrane of …

Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer

B Whitton, H Okamoto, G Packham… - Cancer medicine, 2018 - Wiley Online Library
Abstract Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H+‐transporter that pumps
protons across intracellular and plasma membranes. It consists of a large multi‐subunit …

[HTML][HTML] Regulation and function of V-ATPases in physiology and disease

MP Collins, M Forgac - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2020 - Elsevier
Abstract The vacuolar H+-ATPases (V-ATPases) are essential, ATP-dependent proton
pumps present in a variety of eukaryotic cellular membranes. Intracellularly, V-ATPase …

Enhanced expression of the human vacuolar H+-ATPase c subunit gene (ATP6L) in response to anticancer agents

T Torigoe, H Izumi, H Ishiguchi, H Uramoto… - Journal of Biological …, 2002 - ASBMB
We have isolated two overlapping genomic clones that contain the 5′-terminal portion of
the human vacuolar H+-ATPase c subunit (ATP6L) gene. The sequence preceding the …

[HTML][HTML] Regulation of V-ATPase assembly and function of V-ATPases in tumor cell invasiveness

C McGuire, K Cotter, L Stransky, M Forgac - Biochimica et Biophysica Acta …, 2016 - Elsevier
V-ATPases are ATP-driven proton pumps that function within both intracellular
compartments and the plasma membrane in a wide array of normal physiological and …

Plasmalemmal vacuolar-type H+-ATPase in cancer biology

SR Sennoune, D Luo, R Martinez-Zaguilán - Cell biochemistry and …, 2004 - Springer
Vacuolar-type H+-adenosine triphosphatase (V-ATPase) is one of the most fundamental
enzymes in nature. V-ATPases are responsible for the regulation of proton concentration in …

Function, structure and regulation of the vacuolar (H+)-ATPases

KC Jefferies, DJ Cipriano, M Forgac - Archives of biochemistry and …, 2008 - Elsevier
The vacuolar ATPases (or V-ATPases) are ATP-driven proton pumps that function to both
acidify intracellular compartments and to transport protons across the plasma membrane …