Discovery of a novel series of substituted quinolines acting as anticancer agents and selective EGFR blocker: Molecular docking study
Abstract A Ta 2 O 5-anchored-piperidine-4-carboxylic acid (PPCA) nanoparticle has been
synthesized and characterized. It was then used as a highly effective nanocatalyst for the …
synthesized and characterized. It was then used as a highly effective nanocatalyst for the …
Novel quinoline-3-carboxamides (Part 2): Design, optimization and synthesis of quinoline based scaffold as EGFR inhibitors with potent anticancer activity
RM Aly, RAT Serya, AM El-Motwally, A Esmat… - Bioorganic …, 2017 - Elsevier
EGFR has a key role in cell growth. Its mutation and overexpression share in epithelial
malignancies and tumor growth. Quinazoline and quinoline derivatives are common …
malignancies and tumor growth. Quinazoline and quinoline derivatives are common …
Molecular design and synthesis of certain new quinoline derivatives having potential anticancer activity
DA Ibrahim, DA Abou El Ella, AM El-Motwally… - European Journal of …, 2015 - Elsevier
EGFR, which plays a vital role as a regulator of cell growth, is one of the intensely studied TK
targets of anticancer inhibitors. The most two common anticancer inhibitors are …
targets of anticancer inhibitors. The most two common anticancer inhibitors are …
Design, synthesis and in vitro antitumor activity of 4-aminoquinoline and 4-aminoquinazoline derivatives targeting EGFR tyrosine kinase
Two series of new 6-alkoxy-4-substituted-aminoquinazolines (2–4f) and their bioisoteric
quinoline congeners (5–7c) were designed and synthesized. Virtual screening was carried …
quinoline congeners (5–7c) were designed and synthesized. Virtual screening was carried …
Synthesis and biological evaluation of 2-styrylquinolines as antitumour agents and EGFR kinase inhibitors: molecular docking study
MAA El-Sayed, WM El-Husseiny… - Journal of enzyme …, 2018 - Taylor & Francis
Abstract A new series of 4, 6-disubstituted 2-(4-(dimethylamino) styryl) quinoline 4a, b–9a, b
was synthesized by the reaction of 2-(4-(dimethylamino) styryl)-6-substituted quinoline-4 …
was synthesized by the reaction of 2-(4-(dimethylamino) styryl)-6-substituted quinoline-4 …
Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: molecular docking study
Novel derivatives of quinazoline (1–27) have been synthesized and tested for their antitumor
activity against three tumor cell lines among these cell lines the human breast carcinoma …
activity against three tumor cell lines among these cell lines the human breast carcinoma …
Design, synthesis and assessment of new series of quinazolinone derivatives as EGFR inhibitors along with their cytotoxic evaluation against MCF7 and A549 cancer …
New acetamide (IV ae) and 1, 3-thiazolidinone derivatives (VII ae) were designed,
synthesized and assessed for their cytotoxic activity against MCF-7 and A549 cell lines …
synthesized and assessed for their cytotoxic activity against MCF-7 and A549 cell lines …
Development of penipanoid C-inspired 2-benzoyl-1-methyl-2, 3-dihydroquinazolin-4 (1H)-one derivatives as potential EGFR inhibitors: Synthesis, anticancer …
A novel class of penipanoid C-inspired 2-benzoyl-1-methyl-2, 3-dihydroquinazolin-4 (1H)-
ones (3a-3f) and 1-methyl-2-(3, 4, 5-trihydroxybenzoyl)-2, 3-dihydroquinazolin-4 (1H)-one …
ones (3a-3f) and 1-methyl-2-(3, 4, 5-trihydroxybenzoyl)-2, 3-dihydroquinazolin-4 (1H)-one …
Design, synthesis, antiproliferative activity and docking studies of quinazoline derivatives bearing 2, 3-dihydro-indole or 1, 2, 3, 4-tetrahydroquinoline as potential …
Y OuYang, W Zou, L Peng, Z Yang, Q Tang… - European Journal of …, 2018 - Elsevier
Eight series of quinazoline derivatives bearing 2, 3-dihydro-indole or 1, 2, 3, 4-
tetrahydroquinoline were designed, synthesized and evaluated for the IC 50 values against …
tetrahydroquinoline were designed, synthesized and evaluated for the IC 50 values against …
[PDF][PDF] 6, 7-disubstituted-4-anilinoquinazoline: design, synthesis and anticancer activity as a novel series of potent anticancer agents
Background: Epidermal Growth Factor Receptor (EGFR) and vascular endothelial growth
factor receptor (VEGFR) are responsible for several pathological conditions such as the …
factor receptor (VEGFR) are responsible for several pathological conditions such as the …
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