Purpose Because pH plays a crucial role in several diseases, it is desirable to measure pH
in vivo noninvasively and in a spatially localized manner. Spatial maps of pH were …

pH is a fundamental physiological parameter that is tightly controlled by endogenous
buffers. The acid–base balance is altered in many disease states, such as inflammation …

Objective 13 C metabolic MRI using hyperpolarized 13 C-bicarbonate enables preclinical
detection of pH. To improve signal-to-noise ratio, experimental procedures were refined, and …

Purpose Rapid chemical exchange can affect SNR and pH measurement accuracy for
hyperpolarized pH imaging with [13C] bicarbonate. The purpose of this work was to …

Purpose To produce hyperpolarized bicarbonate indirectly via chemical reaction from a
hyperpolarized precursor and utilize it for the simultaneous regional measurement of …

Purpose To optimize the production of hyperpolarized 13C‐bicarbonate from the
decarboxylation of hyperpolarized [1‐13C] pyruvate and use it to image pH in the lungs and …

Purpose Acquisition timing and B1 calibration are two key factors that affect the quality and
accuracy of hyperpolarized 13C MRI. The goal of this project was to develop a new …

13C Magnetic resonance imaging of hyperpolarized (HP) 13C-enriched bicarbonate
(H13CO3–) and carbon dioxide (13CO2) is a novel and sensitive technique for tissue pH …

As alterations in tissue pH underlie many pathological processes, the capability to image
tissue pH in the clinic could offer new ways of detecting disease and response to treatment …

Hyperpolarization of 13C labeled substrates via dynamic nuclear polarization has been
used as a method to noninvasively study real‐time metabolic processes occurring in vivo. In …