The reactions of the tricarboxylic acid (TCA) cycle allow the controlled combustion of fat and
carbohydrate. In principle, TCA cycle intermediates are regenerated on every turn and can …

The oxidation of acetyl-CoA to CO2 by the TCA1 cycle is the central process in energy
metabolism. However, the TCA cycle also functions in biosynthetic pathways in which …

The hepatic TCA cycle supports oxidative and biosynthetic metabolism. This dual
responsibility requires anaplerotic pathways, such as pyruvate carboxylase (PC), to …

This review presents the concepts of anaplerosis and cataplerosis in relation to the
regulation of citric acid cycle operation. Anaplerosis is the re-filling of the catalytic …

Obesity results from an imbalance in energy homeostasis, whereby excessive energy intake
exceeds caloric expenditure. Energy can be dissipated out of an organism by producing …

The tricarboxylic acid (TCA) cycle is a primordial metabolic pathway that is conserved from
bacteria to humans. Although this network is often viewed primarily as an energy producing …

The central process in energy production is the oxidation of acetyl‐CoA to CO 2 by the
tricarboxylic acid (TCA, Krebs, citric acid) cycle. However, this cycle functions also as a …

The citric acid cycle forms a major metabolic hub and as such it is involved in many disease
states involving energetic imbalance. In spite of the fact that it is being branded as a “cycle” …

Coenzyme A (CoA) is the major acyl group carrier in intermediary metabolism. Hopantenate
(HoPan), a competitive inhibitor of the pantothenate kinases, was used to chemically …

Acetate is a major nutrient that supports acetyl-coenzyme A (Ac-CoA) metabolism and thus
lipogenesis and protein acetylation. However, its source is unclear. Here, we report that …