Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease caused by a
truncated lamin A protein (progerin) that drives cellular and organismal decline. HGPS …

Hutchinson-Gilford progeria syndrome (HGPS) is a lethal genetic disorder characterized by
premature aging. HGPS is most commonly caused by a de novo single-nucleotide …

Abstract Hutchinson-Gilford Progeria Syndrome (HGPS) is a devastating incurable
premature aging disease caused by accumulation of progerin, a toxic lamin A mutant …

Hutchinson-Gilford progeria syndrome (HGPS) is a rare, invariably fatal premature aging
disorder. The disease is caused by constitutive production of progerin, a mutant form of the …

Hutchinson-Gilford progeria syndrome (HGPS) is caused by a mutation in LMNA that
produces an aberrant lamin A protein, progerin. The accumulation of progerin in HGPS cells …

Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant genetic
disease that is caused by a silent mutation of the LMNA gene encoding lamins A and C …

Products of the LMNA gene, primarily lamin A and C, are key components of the nuclear
lamina, a proteinaceous meshwork that underlies the inner nuclear membrane and is …

Lamins are nuclear intermediate filaments. In addition to their structural roles, they are
implicated in basic nuclear functions such as chromatin organization, DNA replication …

The premature-ageing disease Hutchinson-Gilford Progeria Syndrome (HGPS) is caused by
constitutive production of progerin, a mutant form of the nuclear architectural protein lamin …

In humans, aging is characterized by a gradual decline of physical and psychological
functions, with the concomitant onset of chronic-degenerative diseases, which ultimately …