Angiogenesis is a key factor in the carcinogenesis process. In oncological practice,
angiogenesis inhibition, mainly through the blockade of the VEGF family and its receptors …

Angiogenesis is critical for normal and pathologic processes in new blood vessel formation.
A recent significant advance in the treatment of metastatic colorectal cancer has occurred by …

Introduction: Angiogenesis is a complex process regulated by several pro-and anti-
angiogenic factors, thus the loss of its fine equilibrium plays a key role in colorectal cancer …

Angiogenesis, a complex, coordinated process resulting in the assembly and maturation of
new blood vessels, is critical for the growth of tumors. Several lines of evidence argue for …

Angiogenesis is a hallmark of cancer and is regulated by a balance of pro-and anti-
angiogenic factors; among them, the vascular endothelial growth factor (VEGF) is the key …

Vascular endothelial growth factor (VEGF) plays a crucial role in the growth and metastatic
spread of cancer. Bevacizumab (Avastin) is the first commercially available VEGF inhibitor …

Introduction: treatment of colorectal cancer (CRC) has changed dramatically over the past
decade, mainly due to the advent of molecularly targeted agents. In particular, an improved …

The scientific rationale to block angiogenesis as a treatment strategy for human cancer has
been developed over the last 30 years, but is only now entering the clinical arena …

Angiogenesis, the process by which new blood vessels are formed from preexisting vessels,
is essential for growth and progression of solid tumors. A number of growth factors regulate …

Opinion statement Advances in our understanding of the mechanisms underlying tumor
progression suggest that angiogenesis plays a key role in gastrointestinal malignancies …