HuR-targeted agents: an insight into medicinal chemistry, biophysical, computational studies and pharmacological effects on cancer models
G Assoni, V La Pietra, R Digilio, C Ciani… - Advanced Drug Delivery …, 2022 - Elsevier
Abstract The Human antigen R (HuR) protein is an RNA-binding protein, ubiquitously
expressed in human tissues, that orchestrates target RNA maturation and processing both in …
expressed in human tissues, that orchestrates target RNA maturation and processing both in …
HuR as a molecular target for cancer therapeutics and immune-related disorders
M Majumder, P Chakraborty, S Mohan… - Advanced drug delivery …, 2022 - Elsevier
The control of eukaryotic gene expression occurs at multiple levels, from transcription to
messenger RNA processing, transport, localization, turnover, and translation. RNA-binding …
messenger RNA processing, transport, localization, turnover, and translation. RNA-binding …
Targeting the RNA-binding protein HuR in cancer
The RNA-binding protein human antigen R (HuR) is a well-established regulator of gene
expression at the posttranscriptional level. Its dysregulation has been implicated in various …
expression at the posttranscriptional level. Its dysregulation has been implicated in various …
The RNA-binding protein HuR in human cancer: A friend or foe?
The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis
elements present in mRNAs whose stability and translation are subject to regulation. The …
elements present in mRNAs whose stability and translation are subject to regulation. The …
The RNA binding protein HuR: a promising drug target for anticancer therapy
M Wu, CWS Tong, W Yan, KKW To… - Current cancer drug …, 2019 - ingentaconnect.com
The stability of mRNA is one of the key factors governing the regulation of eukaryotic gene
expression and function. Human antigen R (HuR) is an RNA-binding protein that regulates …
expression and function. Human antigen R (HuR) is an RNA-binding protein that regulates …
Interfering with HuR–RNA interaction: design, synthesis and biological characterization of tanshinone mimics as novel, effective HuR inhibitors
L Manzoni, C Zucal, DD Maio… - Journal of Medicinal …, 2018 - ACS Publications
The human antigen R (HuR) is an RNA-binding protein known to modulate the expression of
target mRNA coding for proteins involved in inflammation, tumorigenesis, and stress …
target mRNA coding for proteins involved in inflammation, tumorigenesis, and stress …
Understanding and targeting the disease‐related RNA binding protein human antigen R (HuR)
Altered gene expression is a characteristic feature of many disease states such as
tumorigenesis, and in most cancers, it facilitates cancer cell survival and adaptation …
tumorigenesis, and in most cancers, it facilitates cancer cell survival and adaptation …
Small molecules targeting the RNA-binding protein HuR inhibit tumor growth in xenografts
The RNA-binding protein Hu antigen R (HuR) is a post-transcriptional regulator critical in
several types of diseases, including cancer, making it a promising therapeutic target. We …
several types of diseases, including cancer, making it a promising therapeutic target. We …
Identification and validation of novel small molecule disruptors of HuR-mRNA interaction
HuR, an RNA binding protein, binds to adenine-and uridine-rich elements (ARE) in the 3′-
untranslated region (UTR) of target mRNAs, regulating their stability and translation. HuR is …
untranslated region (UTR) of target mRNAs, regulating their stability and translation. HuR is …
Posttranslational control of HuR function
I Grammatikakis, K Abdelmohsen… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
The RNA‐binding protein HuR (human antigen R) associates with numerous transcripts,
coding and noncoding, and controls their splicing, localization, stability, and translation …
coding and noncoding, and controls their splicing, localization, stability, and translation …