Type I Interferons (IFNs) are hallmark cytokines produced in immune responses to all
classes of pathogens. Type I IFNs can influence dendritic cell (DC) activation, maturation …

Plasmacytoid dendritic cells (pDCs) are specialized producers of type I interferons (IFNs)
that respond to most viruses. Because of their antiviral activity and regulatory functions in …

Type I interferons (IFN) and dendritic cells (DC) share an overlapping history, with rapidly
accumulating evidence for vital roles for both production of type 1 IFN by DC and the …

Type I interferons (IFN-I) were first described over 50 years ago as factors produced by cells
that interfere with virus replication and promote an antiviral state. Innate and adaptive …

Type I interferons (IFNs) are promptly produced upon invasion of pathogens, and activate a
broad range of effector cells in the innate and adaptive immune system. Lin− CD4+ CD11c …

Type I interferons, a protein family of multiple IFNαs and a single IFNβ, initially identified on
the basis of their antiviral activities have recently been attributed important roles in bacterial …

Type I interferons (IFNs) released upon viral infections play different and opposing roles in
disease outcome. This pleiotropic effect is mainly influenced by the cellular sources, timing …

Plasmacytoid dendritic cells (p DC s) are responsible for the robust and immediate
production of type I IFN s during viral infection. p DC s employ TLR 7 and TLR 9 to detect …

One of the most powerful and multifaceted cytokines produced by immune cells are type I
interferons (IFNs), the basal secretion of which contributes to the maintenance of immune …

Type I interferons (IFN-α and IFN-β) were originally described as potent antiviral substances,
which are produced upon infection of animal cells with viruses. Despite a large body of …