The mitochondria are double-membrane organelles integral for energy metabolism.
Mitochondrial dynamics is regulated by inner and outer mitochondrial membrane (IMM and …

Aims The optic atrophy 1 (OPA1) protein is an essential protein involved in the fusion of the
mitochondrial inner membrane. Despite its high level of expression, the role of OPA1 in the …

Mitochondrial dynamics is a conserved process by which mitochondria undergo repeated
cycles of fusion and fission, leading to exchange of mitochondrial genetic content, ions …

Mitochondrial dysfunction occurs during aging, but its impact on tissue senescence is
unknown. Here, we find that sedentary but not active humans display an age-related decline …

Aims Mitochondrial fusion and fission are essential processes for preservation of normal
mitochondrial function. We hypothesized that fusion proteins would be decreased in heart …

Increased levels of the mitochondria-shaping protein Opa1 improve respiratory chain
efficiency and protect from tissue damage, suggesting that it could be an attractive target to …

Mammalian mitochondria are emerging as a critical stress-responsive contributor to cellular
life/death and developmental outcomes. Maintained as an organellar network distributed …

The regulation of mitochondrial dynamics by the GTPase OPA1, which is located at the inner
mitochondrial membrane, is crucial for adapting mitochondrial function and preserving …

Mitochondrial complex I dysfunction has long been associated with Parkinson's disease
(PD). Recent evidence suggests that mitochondrial involvement in PD may extend beyond a …

Opa1 participates in inner mitochondrial membrane fusion and cristae morphogenesis.
Here, we show that muscle‐specific Opa1 ablation causes reduced muscle fiber size …