The blood barriers of the nervous system protect neural environments but can hinder
therapeutic accessibility. The blood-brain barrier (BBB) is well characterized, consisting of …

The vertebrate vasculature displays high organotypic specialization, with the structure and
function of blood vessels catering to the specific needs of each tissue. A unique feature of …

The blood–brain barrier (BBB) is a term used to describe a series of properties possessed
by the vasculature of the central nervous system (CNS) that tightly regulate the movement of …

The blood brain barrier (BBB) specifically regulates molecular and cellular flux between the
blood and the nervous tissue. Our aim was to develop and characterize a highly …

The interface between the blood circulation and the neural tissue features unique
characteristics that are encompassed by the term'blood-brain barrier'(BBB). The main …

Highlights•Transcytosis is actively suppressed in CNS endothelial cells for barrier
integrity.•Transcytosis is dynamically regulated during development and …

Highlights•We review the multi-faceted process of blood–brain barriergenesis.•We outline
the different properties of the BBB and temporal order of appearance.•Focus on cellular …

The microvasculature of the brain forms a protective blood-brain barrier (BBB) that ensures a
homeostatic environment for the central nervous system (CNS), which is essential for …

The blood–brain barrier (BBB) is a selective endothelial interface that controls trafficking
between the bloodstream and brain interstitial space. During development, the BBB arises …

The blood brain barrier (BBB) evolved to preserve the microenvironment of the highly
excitable neuronal cells to allow for action potential generation and propagation. Intricate …