Mechanosensitive ion channels are widely expressed in the cardiovascular system. They
translate mechanical forces including shear stress and stretch into biological signals. The …

Mechanical forces are critical physical cues that can affect numerous cellular processes
regulating the development, tissue maintenance, and functionality of cells. The contribution …

The heart as a contractile hollow organ finely tunes mechanical parameters such as stroke
volume, stroke pressure and cardiac output according to filling volumes, filling pressures via …

The application of mechanical stimuli to cells often induce increases in intracellular calcium,
affecting the regulation of a variety of cell functions. Although the mechanism of …

Mechanical forces will have been omnipresent since the origin of life, and living organisms
have evolved mechanisms to sense, interpret, and respond to mechanical stimuli. The …

Mechanosensitivity in voltage-gated calcium channels could be an asset to calcium
signaling in healthy cells or a liability during trauma. Recombinant N-type channels …

L-type calcium channels are modulated by a host of mechanisms that include voltage,
calcium ions (Ca2+ dependent inactivation and facilitation), cytosolic proteins (CAM …

Stretch-activated or mechanosensitive channels transduce mechanical forces into ion fluxes
across the cell membrane. These channels have been implicated in several aspects of …

Mechanosensitive ion channels comprise a broad group of proteins that sense mechanical
extracellular and intracellular changes, translating them into cation influx to adapt and …

The major players in the processes of cellular mechanotransduction are considered to be
mechanosensitive (MS) or mechano-gated ion channels. Non-selective Ca 2+-permeable …