Animal survival depends on cognitive abilities such as learning and memory to adapt to
environmental changes. Memory functions require an enhanced activity and connectivity of …

Alzheimer's disease (AD) is a neurodegenerative condition characterized by increased
accumulation of Aβ and degeneration of cholinergic signaling between basal forebrain and …

Aging is a complex biological process that increases the risk of age-related cognitive
degenerative diseases such as dementia, including Alzheimer's disease (AD), Lewy Body …

Alzheimer's disease (AD) is the leading cause of dementia affecting over 25 million people
worldwide. Classical studies focused on the description and characterization of the …

The cholinergic system plays an essential role in brain development, physiology, and
pathophysiology. Herein, we review how specific alterations in this system, through genetic …

Nicotinic acetylcholine receptors (nAChRs) are widely distributed throughout the central
nervous system, being expressed in neurons and non-neuronal cells, where they participate …

Neuroinflammation accompanies or even precedes the development of cognitive changes in
many brain pathologies, including Alzheimer's disease. Therefore, dampening inflammatory …

Nicotinic acetylcholine receptors of α7 subtype (α7 nAChRs) are involved in regulating
neuroinflammation and cognitive functions. Correspondingly, α7-/-mice demonstrate pro …

All nervous system pathologies (eg, neurodegenerative/demyelinating diseases and brain
tumours) develop neuroinflammation, a beneficial process during pathological events …

The major addictive component of tobacco, nicotine, exerts anti-inflammatory effects in
multiple cell types and may benefit neurons in various degenerative disorders, such as …