Lipid-lowering therapy with statins, a new approach to antiarrhythmic therapy

J Tamargo, R Caballero, R Gómez, L Núñez… - Pharmacology & …, 2007 - Elsevier
Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (statins) are the
most effective and best-tolerated drugs to treat elevated levels of low-density lipoprotein …

Do statins have an antiarrhythmic activity?

MS Kostapanos, EN Liberopoulos… - Cardiovascular …, 2007 - academic.oup.com
Sudden cardiac death, which is mainly associated with the presence of life-threatening
ventricular arrhythmias, is a common 'killer'among patients with coronary artery disease …

Statins and the reduction of sudden cardiac death: antiarrhythmic or anti-ischemic effect?

A Beri, T Contractor, A Khasnis, R Thakur - American journal of …, 2010 - Springer
Sudden cardiac death is an important cause of cardiovascular mortality with the majority of
cases occurring in low-risk groups. HMG-CoA reductase inhibitors (statins) have recently …

Statins as Anti‐Arrhythmics: A Systematic Review Part II: Effects on Risk of Ventricular Arrhythmias

H Abuissa, JH O'Keefe… - Clinical Cardiology: An …, 2009 - Wiley Online Library
Background Recent studies have demonstrated that statins may possess anti‐arrhythmic
properties in addition to their lipid‐lowering effects. Methods Studies which reported the …

Cholesterol and cardiac arrhythmias

CL Goonasekara, E Balse, S Hatem… - Expert review of …, 2010 - Taylor & Francis
Cardiac arrhythmias are a leading cause of morbidity and mortality in the Western world.
Ventricular arrhythmias are reportedly responsible for the majority of sudden cardiac deaths …

Statins for heart failure: a potential for new treatment

N Haramaki, H Ikeda - Cardiovascular research, 2003 - academic.oup.com
3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, statins, are potent
and widely used cholesterol-lowering drugs. Since the pathophysiology of atherosclerosis …

Statins: powerful drugs for lowering cholesterol: advice for patients

AM Gotto Jr - Circulation, 2002 - Am Heart Assoc
The underlying cause of heart disease is a process called atherosclerosis. Atherosclerosis
has been described simply as hardening of the arteries, but in truth, it involves a complex …

Effect of statins on ventricular tachyarrhythmia, cardiac arrest, and sudden cardiac death: a meta-analysis of published and unpublished evidence from randomized …

K Rahimi, W Majoni, A Merhi… - European heart …, 2012 - academic.oup.com
Aims The effect of statin treatment on ventricular arrhythmic complications is uncertain. We
sought to test whether statins reduce the risk of ventricular tachyarrhythmia, cardiac arrest …

Statins: established indications and controversial subgroups

JW Jukema, SC Bergheanu - Heart, 2008 - heart.bmj.com
Statins are, to date, the most powerful cholesterol lowering drugs. In brief, they inhibit 3-
hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase, which is a key enzyme in the …

Current thinking in statin therapy

P Puddu, GM Puddu, A Muscari - Acta cardiologica, 2001 - Taylor & Francis
The HMG-CoA reductase inhibitors (statins) are now considered the most potent lipid-
lowering drugs. Treatment with statins reduces both morbidity and mortality rates due to …