The current paradigm for treatment of epilepsy begins with trials of antiepileptic drugs,
followed by evaluation for resective brain surgery in drug-resistant patients. If surgery is not …

Background People with epilepsy are burdened with the apparent unpredictability of
seizures. In the past decade, converging evidence from studies using chronic EEG (cEEG) …

To date, the unpredictability of seizures remains a source of suffering for people with
epilepsy, motivating decades of research into methods to forecast seizures. Originally, only …

The cyclical structure of epilepsy was recently (re)-discovered through years-long
intracranial electroencephalography (EEG) obtained with implanted devices. In this review …

Background Longitudinal EEG recorded by implanted devices is critical for understanding
and managing epilepsy. Recent research reports patient-specific, multi-day cycles in device …

Background Seizure prediction would be clinically useful in patients with epilepsy and could
improve safety, increase independence, and allow acute treatment. We did a multicentre …

Importance Focal epilepsy is characterized by the cyclical recurrence of seizures, but, to our
knowledge, the prevalence and patterns of seizure cycles are unknown. Objective To …

Abstract The Epilepsy Innovation Institute (Ei2) is a new research program of the Epilepsy
Foundation designed to be an innovation incubator for epilepsy. Ei2 research areas are …

Epilepsy is among the most dynamic disorders in neurology. A canonical view holds that
seizures, the characteristic sign of epilepsy, occur at random, but, for centuries, humans …

For almost 40 years, neuroscientists thought that epileptic seizures began abruptly, just a
few seconds before clinical attacks. There is now mounting evidence that seizures develop …