[HTML][HTML] Effect of 12-week intake of nicotinamide mononucleotide on sleep quality, fatigue, and physical performance in older Japanese adults: a randomized, double …

M Kim, J Seol, T Sato, Y Fukamizu, T Sakurai, T Okura - Nutrients, 2022 - mdpi.com
Deteriorating sleep quality and physical or mental fatigue in older adults leads to decreased
quality of life and increased mortality rates. This study investigated the effects of the time …

[HTML][HTML] The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind …

L Yi, AB Maier, R Tao, Z Lin, A Vaidya, S Pendse… - Geroscience, 2023 - Springer
In animal studies, β-nicotinamide mononucleotide (NMN) supplementation increases
nicotinamide adenine dinucleotide (NAD) concentrations and improves healthspan and …

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men

J Irie, E Inagaki, M Fujita, H Nakaya, M Mitsuishi… - Endocrine …, 2020 - jstage.jst.go.jp
Recent studies have revealed that decline in cellular nicotinamide adenine dinucleotide
(NAD+) levels causes aging-related disorders and therapeutic approaches increasing …

MIB-626, an oral formulation of a microcrystalline unique polymorph of β-nicotinamide mononucleotide, increases circulating nicotinamide adenine dinucleotide and …

KM Pencina, S Lavu, M Dos Santos… - The Journals of …, 2023 - academic.oup.com
Background Nicotinamide adenine dinucleotide (NAD) precursors, nicotinamide
mononucleotide (NMN), or nicotinamide riboside (NR) extend healthspan and ameliorate …

[HTML][HTML] Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women

Y Fukamizu, Y Uchida, A Shigekawa, T Sato… - Scientific reports, 2022 - nature.com
A decrease in the intracellular level of nicotinamide adenine dinucleotide (NAD+), an
essential coenzyme for metabolic activity, causes various age-related diseases and …

[HTML][HTML] Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study

B Liao, Y Zhao, D Wang, X Zhang, X Hao… - Journal of the International …, 2021 - Springer
Background Recent studies in rodents indicate that a combination of exercise training and
supplementation with nicotinamide adenine dinucleotide (NAD+) precursors has synergistic …

[HTML][HTML] A multicentre, randomised, double blind, parallel design, placebo controlled study to evaluate the efficacy and safety of uthever (NMN supplement), an orally …

H Huang - Frontiers in aging, 2022 - frontiersin.org
Objective: The purpose of the study was to evaluate the anti-aging effect of NMN and its
safety in a double-blind, parallel, randomised controlled clinical trial. Methods: The study …

Sleep health, lifestyle and mental health in the Japanese elderly: ensuring sleep to promote a healthy brain and mind

H Tanaka, S Shirakawa - Journal of psychosomatic research, 2004 - Elsevier
The Ministry of Health, Labor and Welfare in Japan proposed a plan called “Health Japan
21,” which adopted sleep as one of the specific living habits needing improvement. This has …

Nicotinamide mononucleotide ameliorates the depression-like behaviors and is associated with attenuating the disruption of mitochondrial bioenergetics in depressed …

X Xie, C Yu, J Zhou, Q Xiao, Q Shen, Z Xiong… - Journal of affective …, 2020 - Elsevier
Background Nicotinamide mononucleotide (NMN) has been shown to stimulate oxidative
phosphorylation in mitochondria and to improve various pathologies in patients and mouse …

Effects of a month‐long napping regimen in older individuals

SS Campbell, MD Stanchina… - Journal of the …, 2011 - Wiley Online Library
OBJECTIVES: To examine the effects of a month‐long nap regimen using one of two
durations (45 minutes or 2 hours) on nighttime sleep and waking function in a group of …