177Lu-labeled PSMA targeting therapeutic with optimized linker for treatment of disseminated prostate cancer; evaluation of biodistribution and dosimetry

A Abouzayed, K Seitova, F Lundmark… - Frontiers in …, 2023 - frontiersin.org
Introduction Prostate specific membrane antigen (PSMA), highly expressed in metastatic
castration-resistant prostate cancer (mCRPC), is an established therapeutic target …

Trifunctional PSMA-targeting constructs for prostate cancer with unprecedented localization to LNCaP tumors

J Kelly, A Amor-Coarasa, S Ponnala… - European Journal of …, 2018 - Springer
Purpose Treatment of late-stage prostate cancer by targeted radiotherapeutics such as 131 I-
MIP-1095 and 177 Lu-PSMA-617 has shown encouraging early results. Lu-177 is preferred …

Lu-177-Labeled Hetero-Bivalent Agents Targeting PSMA and Bone Metastases for Radionuclide Therapy

Z Zha, K Ploessl, SR Choi, R Zhao, W Jin… - Journal of Medicinal …, 2023 - ACS Publications
Prostate-specific membrane antigen (PSMA) is an excellent target for imaging and
radionuclide therapy of prostate cancer. Recently,[177Lu] Lu-PSMA-617 (Pluvicto) was …

Single low-dose injection of Evans blue modified PSMA-617 radioligand therapy eliminates prostate-specific membrane antigen positive tumors

Z Wang, R Tian, G Niu, Y Ma, L Lang… - Bioconjugate …, 2018 - ACS Publications
Prostate cancer is the most frequently diagnosed malignant tumor in men worldwide.
Prostate-specific membrane antigen (PSMA) is a surface molecule specifically expressed by …

Comparison of novel PSMA-targeting [177Lu] Lu-P17-087 with its albumin binding derivative [177Lu] Lu-P17-088 in metastatic castration-resistant prostate cancer …

L Li, J Wang, G Wang, R Wang, W Jin, J Zang… - European Journal of …, 2024 - Springer
Purpose Prostate-specific membrane antigen (PSMA) is a promising target for diagnosis and
radioligand therapy (RLT) of prostate cancer. Two novel PSMA-targeting radionuclide …

68Ga-and 177Lu-labeled PSMA I&T: optimization of a PSMA-targeted theranostic concept and first proof-of-concept human studies

M Weineisen, M Schottelius, J Simecek… - Journal of Nuclear …, 2015 - Soc Nuclear Med
On the basis of the high and consistent expression of prostate-specific membrane antigen
(PSMA) in metastatic prostate cancer (PC), the goal of this study was the development …

Mono-and multimeric PSMA-targeting small molecule-thorium-227 conjugates for optimized efficacy and biodistribution in preclinical models

N Böhnke, B Indrevoll, S Hammer, A Papple… - European Journal of …, 2024 - Springer
Purpose PSMA (prostate-specific membrane antigen) is highly expressed on prostate
cancer (PrCa) cells and extensively used as a homing target for PrCa treatment. Most …

177Lu-labeled albumin-binder–conjugated PSMA-targeting agents with extremely high tumor uptake and enhanced tumor-to-kidney absorbed dose ratio

HT Kuo, KS Lin, Z Zhang, CF Uribe… - Journal of Nuclear …, 2021 - Soc Nuclear Med
The use of an albumin binder has been shown to improve tumor uptake of prostate-specific
membrane antigen (PSMA)–targeting radiotherapeutic agents. The aim of this study was to …

Preclinical development of a novel [68Ga]Ga-/[177Lu]Lu-labeled agent for PSMA-targeted imaging and therapy

Y Wu, X Zhang, H Zhou, J Zhang - Journal of Radioanalytical and Nuclear …, 2022 - Springer
Prostate-specific membrane antigen (PSMA)-targeted radiolabeled agents have been
developed to diagnose and treat prostate cancer. In this study, we developed a novel 68Ga …

[HTML][HTML] Lutetium-177-labeled prostate-specific membrane antigen-617 for molecular imaging and targeted radioligand therapy of prostate cancer

R Ritawidya, H Wongso, N Effendi… - Advanced …, 2023 - ncbi.nlm.nih.gov
Prostate-specific membrane antigen (PSMA) represents a promising target for PSMA-
overexpressing diseases, especially prostate cancer-a common type of cancer among men …