[HTML][HTML] Biosynthesis of medicinal tropane alkaloids in yeast
P Srinivasan, CD Smolke - Nature, 2020 - nature.com
Tropane alkaloids from nightshade plants are neurotransmitter inhibitors that are used for
treating neuromuscular disorders and are classified as essential medicines by the World …
treating neuromuscular disorders and are classified as essential medicines by the World …
[HTML][HTML] Engineering a microbial biosynthesis platform for de novo production of tropane alkaloids
P Srinivasan, CD Smolke - Nature communications, 2019 - nature.com
Tropane alkaloids (TAs) are a class of phytochemicals produced by plants of the nightshade
family used for treating diverse neurological disorders. Here, we demonstrate de novo …
family used for treating diverse neurological disorders. Here, we demonstrate de novo …
Engineering cellular metabolite transport for biosynthesis of computationally predicted tropane alkaloid derivatives in yeast
P Srinivasan, CD Smolke - Proceedings of the National …, 2021 - National Acad Sciences
Microbial biosynthesis of plant natural products (PNPs) can facilitate access to valuable
medicinal compounds and derivatives. Such efforts are challenged by metabolite transport …
medicinal compounds and derivatives. Such efforts are challenged by metabolite transport …
Complete biosynthesis of noscapine and halogenated alkaloids in yeast
Microbial biosynthesis of plant natural products from simple building blocks is a promising
approach toward scalable production and modification of high-value compounds. The …
approach toward scalable production and modification of high-value compounds. The …
Tropane alkaloid biosynthesis: a centennial review
JP Huang, YJ Wang, T Tian, L Wang, Y Yan… - Natural Product …, 2021 - pubs.rsc.org
Covering: 1917 to 2020 Tropane alkaloids (TAs) are a remarkable class of plant secondary
metabolites, which are characterized by an 8-azabicyclo [3.2. 1] octane (nortropane) ring …
metabolites, which are characterized by an 8-azabicyclo [3.2. 1] octane (nortropane) ring …
[HTML][HTML] A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids
The tetrahydroisoquinoline (THIQ) moiety is a privileged substructure of many bioactive
natural products and semi-synthetic analogs. Plants manufacture more than 3,000 THIQ …
natural products and semi-synthetic analogs. Plants manufacture more than 3,000 THIQ …
Discovery and engineering of colchicine alkaloid biosynthesis
RS Nett, W Lau, ES Sattely - Nature, 2020 - nature.com
Few complete pathways have been established for the biosynthesis of medicinal
compounds from plants. Accordingly, many plant-derived therapeutics are isolated directly …
compounds from plants. Accordingly, many plant-derived therapeutics are isolated directly …
A Root-Expressed l-Phenylalanine:4-Hydroxyphenylpyruvate Aminotransferase Is Required for Tropane Alkaloid Biosynthesis in Atropa belladonna
MA Bedewitz, E Góngora-Castillo, JB Uebler… - The Plant …, 2014 - academic.oup.com
The tropane alkaloids, hyoscyamine and scopolamine, are medicinal compounds that are
the active components of several therapeutics. Hyoscyamine and scopolamine are …
the active components of several therapeutics. Hyoscyamine and scopolamine are …
[HTML][HTML] Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family
F Zhang, F Qiu, J Zeng, Z Xu, Y Tang, T Zhao… - Nature …, 2023 - nature.com
Tropane alkaloids (TAs) are widely distributed in the Solanaceae, while some important
medicinal tropane alkaloids (mTAs), such as hyoscyamine and scopolamine, are restricted …
medicinal tropane alkaloids (mTAs), such as hyoscyamine and scopolamine, are restricted …
A metabolic regulon reveals early and late acting enzymes in neuroactive Lycopodium alkaloid biosynthesis
Plants synthesize many diverse small molecules that affect function of the mammalian
central nervous system, making them crucial sources of therapeutics for neurological …
central nervous system, making them crucial sources of therapeutics for neurological …