This introductory article should be viewed as a prologue to the Free Radical Biology &
Medicine Special Issue devoted to the important topic of Oxidatively Damaged DNA and its …

Endogenous and exogenous sources cause oxidatively induced DNA damage in living
organisms by a variety of mechanisms. The resulting DNA lesions are mutagenic and …

DNA repair limits the mutagenic, and thereby the carcinogenic, effect of DNA modifications.
Free radicals, particularly reactive oxygen species, induce all forms of DNA damage …

Genomes are damaged by spontaneous decay, chemicals, radiation and replication errors.
DNA damage may cause mutations resulting in inheritable disease, cancer and ageing …

DNA is subjected to several modifications, resulting from endogenous and exogenous
sources. The cell has developed a network of complementary DNA-repair mechanisms, and …

Introduction 3. Oxidative DNA damage 3.1. Base modifications 3.2. Deoyxribose products 4.
Repair mechanisms for oxidative DNA damage 4.1. Repair of base damages 4.2. Repair of …

Since DNA is prone to oxidative attack cells have evolved multiple protective strategies to
prevent the deleterious effects of DNA oxidation. Base excision repair is the major …

Oxidative DNA damage has been implicated in mutagenesis, carcinogenesis and aging.
Endogenous cellular processes such as aerobic metabolism generate reactive oxygen …

The generation of reactive oxygen species may be both beneficial to cells, performing a
function in inter-and intracellular signalling, and detrimental, modifying cellular …

Reactive oxygen species are formed constantly in living organisms, as products of the
normal metabolism, or as a result of many different environmental influences. Here we …