Despite the central role of IFN-γ in vitiligo pathogenesis, systemic IFN-γ neutralization is an
impractical treatment option owing to strong immunosuppression. However, most patients …

Vitiligo is an autoimmune disease of the skin causing disfiguring patchy depigmentation of
the epidermis and, less commonly, hair. Therapeutic options for vitiligo are limited, reflecting …

Background Vitiligo is an autoimmune disease that progressively destroys melanocytes in
the skin, resulting in patchy disfiguring depigmentation. The direct pathological effect of IFN …

Vitiligo is an autoimmune disease of the skin that targets pigment-producing melanocytes
and results in patches of depigmentation that are visible as white spots. Recent research …

Vitiligo is an autoimmune skin disease in which epidermal melanocytes are targeted for
destruction by CD8+ T cells specific for melanocyte/melanoma‐shared antigens. IFNγ is the …

Vitiligo is an autoimmune disease of the skin that results in the destruction of melanocytes
and the clinical appearance of white spots. Disease pathogenesis depends on IFN-γ and …

Although the precise mechanisms that trigger vitiligo remain elusive, autoimmune responses
mediate its progression. The development of therapies has been impeded by a paucity of …

Immune‐mediated responses are consistently observed in progressing vitiligo at the edge of
depigmenting patches. Besides the role of the adaptive immune system, the profile of the …

Vitiligo is an autoimmune disease of the skin mediated by CD8+ T cells that kill melanocytes
and create white spots. Skin lesions in vitiligo frequently return after discontinuing …

Purpose: Vitiligo is a T cell-mediated skin depigmentation disease. Though treatments
arresting disease progression and inducing repigmentation are available, the efficacy of …