The lymphatic system serves an integral role in fluid homeostasis, lipid metabolism and
immune control. In cancer, the lymph nodes that drain solid tumours are a primary site of …

The lymphatics transport material from peripheral tissues to lymph nodes, where immune
responses are formed, before being transported into systemic circulation. With key roles in …

Introduction: The lymphatic system has a critical role in the immune system's recognition and
response to disease and it is an additional circulatory system throughout the entire body …

Lymphatic vessels are the primary route of communication from peripheral tissues to the
immune system; as such, they represent an important component of local immunity. In …

Traditionally, tumor-associated lymphatic vessels have been regarded as passive by-
standers, serving simply as a drainage system for interstitial fluid generated within the tumor …

This paper presents an overview of the anatomy, physiology, and biology of the lymphatic
system specifically relevant to lymphatic drug delivery. We will briefly review the classic fluid …

Adaptive immune response consists of many highly regulated, multistep cascades that
protect against infection while preserving the health of autologous tissue. The proper …

Advances in our understanding of the structure and function of the lymphatic system have
made it possible to identify its role in a variety of disease processes. Because it is involved …

The lymphatic system plays a crucial role in the immune system's recognition and response
to disease, and most solid cancers initially spread from the primary site via the tumor's …

Highlights•Tumours induce growth and remodelling of lymphatics which is linked with
metastasis.•Lymphatic vessels modulate antitumour immunity in tumours and draining lymph …