In the past twenty years, the number of adults with diabetes has tripled. Most studies have
been conducted using rodent models of type 2 diabetes mellitus (T2DM), and the developed …

The establishment of rat models of type 2 diabetes mellitus can provide an ideal animal
experimental technology platform for the research of pathogenesis, prevention, diagnosis …

Streptozotocin (STZ) given intravenously destroys pancreatic beta cells and is widely used
in animal models to mimic type 1 diabetes. The effects of STZ on the clinical state of health …

Objective To establish type 2 diabetes mellitus (T2DM) KM mouse models via the combined
use of high-calorie diet and multiple administration of low-dose streptozotocin (STZ) …

Type 1 diabetes mellitus (T1DM) is a chronic disease represented by insulin-causing
pancreatic β-cell disruption and hyperglycemia. Therefore, it is necessary to establish a …

The effects of streptozotocin (STZ) were studied in eight high-health herd-certified
Yorkshire× Swedish Landrace pigs (32.5±2.6 kg initial body weight [BW]), and an insulin …

Background: The previously established methods for type 2 diabetes (T2D) have mainly
concentrated on overt diabetes model development. Here, our intention was to create an …

Introduction: New preventive and therapeutic strategies to treat Type 2 diabetes (T2D)
continue to be pursued, the complexity of this disease makes it imperative to establish …

Prevalence of diabetes, a serious public health problem is rapidly increasing worldwide.
Type-2 diabetes is the common form of diabetes characterized by insulin resistance and …

Background Studies with murine model have been extensively used as a tool in the
understanding of mechanisms involved in diseases such as diabetes (Correia-Santos et al …