Increased nuclear localization of transcription factor YB-1 in acquired cisplatin-resistant ovarian cancer

H Yahata, H Kobayashi, T Kamura, S Amada… - Journal of cancer …, 2002 - Springer
Purpose. Nuclear expression of Y box-binding protein (YB-1), a member of the DNA-binding
protein family, was recently reported to have a much higher concentration in cisplatin …

Is nuclear expression of Y box‐binding protein‐1 a new prognostic factor in ovarian serous adenocarcinoma?

T Kamura, H Yahata, S Amada… - … Journal of the …, 1999 - Wiley Online Library
BACKGROUND Nuclear expression of Y box‐binding protein (YB‐1), a member of the DNA
binding protein family, has been reported to be much more highly concentrated in cisplatin …

Akt-dependent nuclear localization of Y-box-binding protein 1 in acquisition of malignant characteristics by human ovarian cancer cells

Y Basaki, F Hosoi, Y Oda, A Fotovati, Y Maruyama… - Oncogene, 2007 - nature.com
Abstract Y-box-binding protein 1 (YB-1), which is a member of the DNA-binding protein
family containing a cold-shock domain, has pleiotropic functions in response to various …

Nuclear expression of Y box binding-1 is important for resistance to chemotherapy including gemcitabine in TP53-mutated bladder cancer

T Yamashita, M Higashi… - International …, 2017 - spandidos-publications.com
The development and acquisition of multiple drug resistance in cancer cells remain a major
obstacle in the treatment of bladder cancer. Nuclear translocation of Y box binding-1 (YB-1) …

NONO and RALY proteins are required for YB-1 oxaliplatin induced resistance in colon adenocarcinoma cell lines

SP Tsofack, C Garand, C Sereduk, D Chow, M Aziz… - Molecular cancer, 2011 - Springer
Background YB-1 is a multifunctional protein that affects transcription, splicing, and
translation. Overexpression of YB-1 in breast cancers causes cisplatin resistance. Recent …

Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen

T Ise, G Nagatani, T Imamura, K Kato, H Takano… - Cancer research, 1999 - AACR
The Y-box binding protein (YB-1) binds to inverted CCAAT box sequences that are present
in the promoter region of many genes. We previously showed that YB-1 is overexpressed in …

Prognostic implications of the nuclear localization of Y‐box‐binding protein‐1 and CXCR4 expression in ovarian cancer: Their correlation with activated Akt, LRP/MVP …

Y Oda, Y Ohishi, Y Basaki, H Kobayashi… - Cancer …, 2007 - Wiley Online Library
The nuclear localization of Y‐box‐binding protein‐1 (YB‐1) is known to be a poor prognostic
factor in several human malignancies, including ovarian carcinoma. Following on from our …

The strand separation and nuclease activities associated with YB-1 are dispensable for cisplatin resistance but overexpression of YB-1 in MCF7 and MDA-MB-231 …

D Guay, AA Evoy, É Paquet, C Garand… - The international journal …, 2008 - Elsevier
YB-1 is a protein involved in DNA repair, transcription, splicing, translation, and confers
cisplatin resistance in several cancers. However, it is unknown which YB-1 activity is …

Overexpression of Y-box binding protein-1 in cervical cancer and its association with the pathological response rate to chemoradiotherapy

Y Zhang, SR Reng, L Wang, L Lu, ZH Zhao, ZK Zhang… - Medical Oncology, 2012 - Springer
The aim of this study was to evaluate the expression of Y-box binding protein-1 (YB-1) in
nonneoplastic cervical tissue and cervical cancer tissue and to evaluate its relationship with …

[HTML][HTML] Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target

PK Maurya, A Mishra, BS Yadav, S Singh… - Journal of …, 2017 - ncbi.nlm.nih.gov
The Y-box binding protein (YB-1) is known to be a multifunctional transcription and
translation factor during expression of several proteins. It is a vital oncoprotein that regulates …