Methotrexate (MTX) is a drug used in the treatment of various types of cancer and
inflammatory diseases, but its clinical use has been restricted due to its toxicity. Apigenin …

Methotrexate (MTX) is used as an effective chemotherapeutic agent against autoimmune
diseases and tumors. Oxidative stress and inflammation are involved in the pathogenesis of …

Gentamicin (GM) is an aminoglycoside antibiotic used to treat bacterial infections. However,
its application is accompanied by renal impairments. Apigenin is a flavonoid found in many …

Methotrexate (MTX), a chemotherapeutic and immunosuppressant drug, is generally well-
tolerated by most patients. However, its cytotoxic nature contributes to life-threatening side …

Apigenin, a dietary flavonoid, is reported to have several therapeutic effects in different
diseases including cancer. Toxicity of Apigenin is however, least explored, and reports are …

The clinical use of drugs used in the treatment of diseases is limited due to the toxic side
effects, and many studies have been conducted to benefit from herbal adjuvant therapies …

Despite its effectiveness in treating inflammatory diseases and various malignancies,
methotrexate (MTX) is well known to cause hepatotoxicity, which involves increased …

Methotrexate (MTX) is an effectively used drug in the treatment of cancer and inflammatory
diseases but, its use is related with hepatotoxicity. Inulin with antioxidant properties has …

Objectives This study aimed to investigate the antioxidant and anti-inflammatory effects of
caffeic acid phenethyl ester (CAPE) on the methotrexate (MTX)-induced hepatorenal …

Context: Currently, the outcomes of the use of cisplatin in cancer therapy is limited by
nephrotoxicity. Objective: This study aims to investigate the nephroprotective role of …