The nasal epithelium lining the human upper airway is the primary portal of entry for several
respiratory pathogens, including the recently emerged SARS-CoV-2 virus responsible for …

The global urgency to uncover medical countermeasures to combat the COVID-19
pandemic caused by the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) …

Three highly pathogenic human coronaviruses (HCoVs)-SARS-CoV (2002), MERS-CoV
(2012), and SARS-CoV-2 (2019)-have emerged and caused significant public health crises …

Primary differentiated human epithelial cell cultures have been widely used by researchers
to study viral fitness and virus-host interactions, especially during the COVID19 pandemic …

Primary airway epithelial cells (pAECs) cultivated at air-liquid interface (ALI) conditions are
widely used as surrogates for human in vivo epithelia. To extend the proliferative capacity …

Respiratory epithelial cells fail to exhibit natural phenotypic and morphological
characteristics when grown in standard cell culture conditions. To better understanding …

The dynamics of SARS-CoV-2 infection in COVID-19 patients are highly variable, with a
subset of patients demonstrating prolonged virus shedding, which poses a significant …

The mucociliary airway epithelium lines the human airways and is the primary site of host-
environmental interactions in the lung. Following virus infection, airway epithelial cells …

The nasal epithelium is the initial entry portal and primary barrier to infection by all human
coronaviruses (HCoVs). We utilize primary human nasal epithelial cells grown at air–liquid …

Infection biology and pathogenesis of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19), are …