ApoE4, an apolipoprotein implicated in cholesterol transport and amyloid-β (Aβ)
metabolism, is a major genetic risk determinant for Alzheimer's Disease (AD) and drives its …

ApoE4 is a major genetic risk determinant for Alzheimer's disease (AD) and drives its
pathogenesis via Aβ-dependent and-independent pathways. C/EBPβ, a proinflammatory …

Significant knowledge about the pathophysiology of Alzheimer's disease (AD) has been
gained in the last century; however, the understanding of its causes of onset remains limited …

Alzheimer's disease (AD) is the leading cause of dementia affecting almost 50 million
people worldwide. The ε4 allele of Apolipoprotein E (APOE) is the strongest known genetic …

APOE4 is the greatest genetic risk factor for late-onset Alzheimer's disease (AD), increasing
the risk of developing the disease by 3-fold in the 14% of the population that are carriers …

Alzheimer's disease (AD) is an immutable neurodegenerative disease featured by the two
hallmark brain pathologies that are the extracellular amyloid ß (Aß) and intraneuronal tau …

In blood, apolipoprotein E (ApoE) is a component of circulating lipoproteins and mediates
the clearance of these lipoproteins from blood by binding to ApoE receptors. Humans …

Human apolipoprotein (APO) E has three common isoforms that differentially affect lipid and
neuronal homeostasis. APOE4, the major known genetic risk factor for Alzheimer's disease …

Polymorphisms in the apolipoprotein E (APOE) gene affect the risk of Alzheimer disease and
the amount of amyloid β‐protein (Aβ) deposited in the brain. The apoE protein reduces Aβ …

Abstract The Apolipoprotein E ε4 (ApoE ε4) allele, encoding ApoE4, is the strongest genetic
risk factor for late-onset Alzheimer's disease (LOAD). Emerging epidemiological evidence …